Document Detail

First-trimester vaginal bleeding and complications later in pregnancy.
MedLine Citation:
PMID:  20410766     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the association of first-trimester bleeding without miscarriage and complications later in the first pregnancy as well as in the next pregnancy. METHODS: In a retrospective, registry-based cohort study, we identified women delivering in Denmark from 1978 to 2007 with a first singleton pregnancy (n=782,287) and first and second singleton pregnancies (n=536,419). First-trimester bleeding is defined as vaginal bleeding before 12 full weeks of gestation. We employed multivariate logistic regression with adjustment for maternal age and calendar year. RESULTS: First-trimester bleeding increased the risk of delivery in weeks 32-36 from 3.6% to 6.1% (odds ratio [OR], 1.65; 95% confidence interval [CI], 1.57-1.77) and in weeks 28-31 from 0.3% to 0.9% (OR 2.98; 95% CI 2.50-3.54) and increased the risk of placental abruption from 1.0% to 1.4% (OR 1.48; 95% CI 1.30-1.68). First-trimester bleeding in the first pregnancy increased the risk of recurrence in the second pregnancy from 2.2% to 8.2% (OR 4.05; 95% CI 3.78-4.34), preterm delivery from 2.7% to 4.8% (OR 1.83; 95% CI 1.67-2.00), and placental abruption from 0.9% to 1.0% (OR 1.29; 95% CI 1.07-1.56) in the second pregnancy. CONCLUSION: Women with first-trimester bleeding in the first pregnancy have an increased risk of complications later in the first pregnancy and of recurrence of first-trimester bleeding and other complications in the second pregnancy.
Jacob Alexander Lykke; Katrine Lehrmann Dideriksen; Ojvind Lidegaard; Jens Langhoff-Roos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  115     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-22     Completed Date:  2010-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  935-44     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Roskilde Hospital, Roskilde, Denmark.
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MeSH Terms
Confounding Factors (Epidemiology)
Denmark / epidemiology
Fetal Membranes, Premature Rupture / epidemiology
Obstetric Labor, Premature / epidemiology
Pregnancy Complications / epidemiology*
Pregnancy Outcome / epidemiology
Pregnancy Trimester, First
Retrospective Studies
Risk Assessment
Uterine Hemorrhage / epidemiology*
Young Adult

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