| First-trimester ultrasound dating of twin pregnancy: are singleton charts reliable? | |
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MedLine Citation:
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PMID: 20482534 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to assess the performance of validated singleton crown-rump length (CRL) formulae in dating twin pregnancies at 11-14 weeks of gestation. DESIGN: Retrospective cohort study. SETTING: Fetal medicine unit of a London teaching hospital. SAMPLE: Three hundred and eighty-four pregnancies with known dates of conception. METHODS: Retrospective analysis of 266 singletons and 118 twin pregnancies conceived by in vitro fertilisation (IVF), with a known date of conception. The gestation calculated from the date of conception was compared with the expected gestation from fetal size using a number of different CRL formulae. MAIN OUTCOME MEASURES: Difference in gestational age computed from fetal size (CRL) of the bigger and smaller fetus in twin pregnancies and singleton pregnancies using three formulae. RESULTS: Two of the three studied CRL formulae systematically underestimated the mean gestational age and size of singleton IVF pregnancies (Robinson formula: gestation = 1.4 days, size = 2.7 mm). Twin CRL measurements straddled those of singletons, regardless of the CRL formula used (Robinson formula: larger twin gestation = 2.4 days, size = 4.7 mm; smaller twin gestation = 0.8 days, size = 1.7 mm). These underestimates in gestation and size for IVF singleton and twin pregnancies are well within the known limits of accuracy of first = trimester ultrasound measurements, and are of limited clinical significance. CONCLUSIONS: Currently available CRL charts underestimate both the age and size of IVF singleton pregnancies by a clinically insignificant amount. This difference is similar for twin pregnancies, suggesting that singleton CRL charts can be used to date twin pregnancies accurately. |
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Authors:
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T Dias; S Mahsud-Dornan; B Thilaganathan; A Papageorghiou; A Bhide |
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Publication Detail:
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Type: Journal Article Date: 2010-05-19 |
Journal Detail:
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Title: BJOG : an international journal of obstetrics and gynaecology Volume: 117 ISSN: 1471-0528 ISO Abbreviation: BJOG Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-11 Completed Date: 2010-09-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100935741 Medline TA: BJOG Country: England |
Other Details:
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Languages: eng Pagination: 979-84 Citation Subset: AIM; IM |
Affiliation:
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Fetal Medicine Unit, Academic Department of Obstetrics and Gynaecology, St George's Hospital Medical School, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Crown-Rump Length* Female Fertilization in Vitro Fetal Development / physiology* Gestational Age Humans Pregnancy Pregnancy Trimester, First Pregnancy, Multiple / physiology* Reference Values Retrospective Studies Twins Ultrasonography, Prenatal / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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