| First trimester ultrasonography in screening and detection of fetal anomalies. | |
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MedLine Citation:
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PMID: 17304542 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An obstetrical ultrasound examination provides invaluable information regarding the fetus. Until the mid-1980s, ultrasound in the first trimester was limited to localization of the pregnancy, establishing viability, and accurate dating. With the advent of high-resolution ultrasound and transvaginal scanning, a significant amount of information about the fetus can be gained and provided to the patient at a very early stage in gestation. This article provides an overview of the role of first trimester (11-13 + 6 weeks' gestation) ultrasound in screening and diagnosis of fetal anomalies. The first trimester is an ideal time for screening for aneuploidy, primarily due to the advantages that nuchal translucency (NT) measurement provides. NT measurement is also useful in establishing the risk of congenital cardiac disorders and a number of genetic and non-genetic syndromes. Significant NT thickening is associated with an increase in perinatal morbidity and mortality. Potential mechanisms resulting in increased NT are discussed. A number of new ultrasound markers for fetal aneuploidy have been investigated over the past several years, some of which appear to improve the screening efficacy of early ultrasonography. The role of these is reviewed. A number of fetal anomalies can now be consistently diagnosed in the first trimester. Their appearance at this early gestational age is discussed as well. It is clear that, data obtained by first trimester ultrasound are useful in counseling expectant parents and in planning the appropriate follow-up. |
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Authors:
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Jiri Sonek |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American journal of medical genetics. Part C, Seminars in medical genetics Volume: 145C ISSN: 1552-4868 ISO Abbreviation: - Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-27 Completed Date: 2007-05-29 Revised Date: 2008-05-21 |
Medline Journal Info:
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Nlm Unique ID: 101235745 Medline TA: Am J Med Genet C Semin Med Genet Country: United States |
Other Details:
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Languages: eng Pagination: 45-61 Citation Subset: IM |
Copyright Information:
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(c) 2007 Wiley-Liss, Inc. |
Affiliation:
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Maternal-Fetal Medicine/Ultrasound and Genetics, Miami Valley Hospital, Dayton, OH 45409, USA. JDSonek@mvh.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aneuploidy Biological Markers / analysis Female Fetus / abnormalities*, physiopathology Humans Nuchal Translucency Measurement / methods* Pregnancy Pregnancy Trimester, First* Ultrasonography, Doppler Ultrasonography, Prenatal / methods* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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