Document Detail

First trimester sex hormone-binding globulin and subsequent development of preeclampsia or other adverse pregnancy outcomes.
MedLine Citation:
PMID:  16263602     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate whether first trimester maternal serum sex hormone-binding globulin (SHBG) concentrations are altered in women who subsequently develop preeclampsia or other pregnancy complications.
POPULATION: Women undergoing first trimester combined ultrasound and biochemical screening for chromosomal anomalies. We searched the database and identified 32 pregnancies resulting in miscarriage, 64 pregnancies with preexisting or gestational diabetes mellitus, 107 with fetal growth restriction, 103 with preeclampsia, 64 with pregnancy-induced hypertension, and 26 with spontaneous preterm delivery. We also selected 400 controls from among the population of pregnancies that had a delivery of a normal baby with no pregnancy complications.
METHODS: Maternal serum SHBG concentrations were measured retrospectively using a competitive chemiluminescent immunoassay. The levels between those with normal outcome and those resulting in adverse outcome were compared.
RESULTS: The median maternal serum SHBG concentration was not significantly different from controls, in those that subsequently developed preeclampsia (median MoM 1.05), non-proteinuric hypertension (median MoM 0.94) or preterm delivery (median MoM 1.15). The levels were significantly lower in those with diabetes (median MoM, 0.81 p=0.0005) and those pregnancies resulting in miscarriage (median MoM 0.80, p=0.008).
CONCLUSION: First trimester maternal serum SHBG concentrations are no different from controls in women who subsequently develop preeclampsia, pregnancy-induced hypertension, fetal growth restriction, or preterm delivery. Levels are reduced in those who subsequently miscarry or in those presenting with diabetes.
Kevin Spencer; Christina K H Yu; George Rembouskos; Renu Bindra; Kypros H Nicolaides
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  24     ISSN:  1064-1955     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2005  
Date Detail:
Created Date:  2005-11-02     Completed Date:  2006-05-04     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  303-11     Citation Subset:  IM    
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MeSH Terms
Diabetes, Gestational / blood
Fetal Growth Retardation / blood
Obstetric Labor, Premature / blood
Pre-Eclampsia / blood*
Pregnancy Complications / blood*
Pregnancy Outcome
Pregnancy Trimester, First
Retrospective Studies
Sex Hormone-Binding Globulin / metabolism*
Reg. No./Substance:
0/Sex Hormone-Binding Globulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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