| First-trimester screening with nasal bone in twins. | |
MedLine Citation:
|
PMID: 18771984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The purpose of this study was to evaluate the Down syndrome detection rate at a 5% screen positive rate in first-trimester screening for twins. STUDY DESIGN: This was a retrospective study from August 2005 to July 2007 of twins who underwent first-trimester screening with nuchal translucency, nasal bone, pregnancy-associated plasma protein-A, and free beta-hCG. Risks were calculated on the basis of the Fetal Medicine Foundation twin algorithm. The model simulated distributions of unaffected and affected cases at 12 weeks of gestation. RESULTS: Two thousand ninety-four twin pregnancies (4188 fetuses) met the inclusion criteria. The addition of nasal bone to nuchal translucency, pregnancy-associated plasma protein-A, and free beta-hCG increased the Down syndrome detection rate from 79-89% at a 5% screen-positive rate. CONCLUSION: In twins, first-trimester screening with nasal bone is valuable. The improved Down syndrome detection rate can help these high-risk patients with the decision-making process of whether to pursue invasive testing with its associated pregnancy loss risk. |
Authors:
|
Jane Cleary-Goldman; Andrei Rebarber; David Krantz; Terrence Hallahan; Daniel Saltzman |
Related Documents
:
|
15590454 - Placental growth hormone in down's syndrome screening. 16710884 - Sequential triage in the first trimester may enhance advanced ultrasound scanning in po... 10881644 - Screening for hyperglycaemia in pregnancy: analysis of two screening protocols and revi... 15360114 - Indications for fetal echocardiography. 19043774 - Successful pregnancy after rituximab in a women with recurrent in vitro fertilisation f... 1431774 - Supraventricular tachycardia resistant to treatment in a pregnant woman. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of obstetrics and gynecology Volume: 199 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2008 Sep |
Date Detail:
|
Created Date: 2008-09-05 Completed Date: 2008-10-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
|
Languages: eng Pagination: 283.e1-3 Citation Subset: AIM; IM |
Affiliation:
|
Mount Sinai Medical Center, New York, NY, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Chorionic Gonadotropin, beta Subunit, Human / blood Down Syndrome / diagnosis*, ultrasonography Female Humans Maternal Age Nuchal Translucency Measurement Pregnancy Pregnancy Trimester, First Pregnancy-Associated Plasma Protein-A / analysis Retrospective Studies Twins* |
| Chemical | |
Reg. No./Substance:
|
0/Chorionic Gonadotropin, beta Subunit, Human; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of the efficiency of second-trimester nasal bone hypoplasia and increased nuchal fold in ...
Next Document: Evaluating the incidence and likelihood ratios for chromosomal abnormalities in fetuses with common ...