| First trimester screening for Down's syndrome after assisted reproductive technology: non-male factor infertility is associated with elevated free beta-human chorionic gonadotropin levels at 10-14 weeks of gestation. | |
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MedLine Citation:
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PMID: 18164000 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We retrospectively compared the first trimester Down's syndrome serum screening markers free beta-hCG (fbetahCG) and pregnancy-associated plasma protein-A (PAPP-A) at 11-14 weeks of gestation in 4,088 women with naturally conceived pregnancies and in women pregnant after ICSI (n = 163), IVF (n = 59) and frozen-thawed embryo transfer (n = 31), and we searched for a potential relationship between infertility cause and marker levels. We found lower serum PAPP-A levels in pregnancies after IVF and ICSI compared with spontaneously conceived pregnancies and non-male factor infertility was associated with elevated serum fbetahCG levels at 11-14 weeks of gestation. |
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Authors:
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Ellen Anckaert; Johan Schiettecatte; Elke Sleurs; Paul Devroey; Johan Smitz |
Publication Detail:
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Type: Journal Article Date: 2007-12-27 |
Journal Detail:
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Title: Fertility and sterility Volume: 90 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-20 Completed Date: 2008-11-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1206-10 Citation Subset: IM |
Affiliation:
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Laboratory Hormonology and Tumour Markers, Universitair Ziekenhuis Brussel, B-1090 Brussels, Belgium. Ellen.Anckaert@uzbrussel.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Belgium / epidemiology Biological Markers / blood Chorionic Gonadotropin, beta Subunit, Human / blood* Down Syndrome / blood, diagnosis*, embryology, epidemiology* Female Humans Incidence Infertility, Female / blood*, diagnosis, epidemiology* Mass Screening / methods, statistics & numerical data* Pregnancy Pregnancy Trimester, First / blood Prenatal Diagnosis / methods, statistics & numerical data* Retrospective Studies Risk Assessment / methods Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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