Document Detail

First trimester screening for Down's syndrome after assisted reproductive technology: non-male factor infertility is associated with elevated free beta-human chorionic gonadotropin levels at 10-14 weeks of gestation.
MedLine Citation:
PMID:  18164000     Owner:  NLM     Status:  MEDLINE    
We retrospectively compared the first trimester Down's syndrome serum screening markers free beta-hCG (fbetahCG) and pregnancy-associated plasma protein-A (PAPP-A) at 11-14 weeks of gestation in 4,088 women with naturally conceived pregnancies and in women pregnant after ICSI (n = 163), IVF (n = 59) and frozen-thawed embryo transfer (n = 31), and we searched for a potential relationship between infertility cause and marker levels. We found lower serum PAPP-A levels in pregnancies after IVF and ICSI compared with spontaneously conceived pregnancies and non-male factor infertility was associated with elevated serum fbetahCG levels at 11-14 weeks of gestation.
Ellen Anckaert; Johan Schiettecatte; Elke Sleurs; Paul Devroey; Johan Smitz
Publication Detail:
Type:  Journal Article     Date:  2007-12-27
Journal Detail:
Title:  Fertility and sterility     Volume:  90     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-20     Completed Date:  2008-11-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1206-10     Citation Subset:  IM    
Laboratory Hormonology and Tumour Markers, Universitair Ziekenhuis Brussel, B-1090 Brussels, Belgium.
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MeSH Terms
Belgium / epidemiology
Biological Markers / blood
Chorionic Gonadotropin, beta Subunit, Human / blood*
Down Syndrome / blood,  diagnosis*,  embryology,  epidemiology*
Infertility, Female / blood*,  diagnosis,  epidemiology*
Mass Screening / methods,  statistics & numerical data*
Pregnancy Trimester, First / blood
Prenatal Diagnosis / methods,  statistics & numerical data*
Retrospective Studies
Risk Assessment / methods
Risk Factors
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human

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