Document Detail

First trimester screening for Down syndrome in rhesus negative women.
MedLine Citation:
PMID:  18318000     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To explore the effect of maternal rhesus status on first-trimester screening markers for Down syndrome. METHODS: We accessed a database of singleton pregnancies undergoing first-trimester genetic screen with maternal Rh status documented and pregnancy outcome information available. Excluded were cases of fetal chromosomal or structural abnormalities, or maternal systemic disease. Results of maternal serum pregnancy-associated plasma protein A (PAPP-A) and beta-human chorionic gonadotrophin (beta-hCG) adjusted for gestational age were compared between Rh-negative and Rh-positive women with p < 0.05 considered significant. RESULTS: Two thousand two hundred and two pregnancies fulfilled the study criteria, and 160 of them (7%) were Rh negative. Only free beta-hCG corrected multiples of the median (MoM) values were statistically increased in Rh-negative women (p < 0.009). Using a cut-off of 1:300, screen-positive rates of maternal serum biochemistry were not significantly different between Rh-negative and Rh-positive women (12.5 vs 10.4%, p = 0.41). CONCLUSION: The present study focused on measurements of beta-hCG and PAPP-A in the sera of women with Rh-negative blood group. Women with Rh-negative blood type have similar first-trimester serum PAPP-A MoM values as Rh-positive women, but significantly higher beta-hCG MoM values. However, there was no significant difference in the screen-positive rate for Down syndrome between the two groups.
Murat Muhcu; Ercument Mungen; Vedat Atay; Osman Metin Ipcioglu; Ozgur Dundar; Rustu Ergur; Yusuf Ziya Yergok
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  28     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-05     Completed Date:  2008-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  404-7     Citation Subset:  IM    
Copyright Information:
2008 John Wiley & Sons, Ltd
GATA Haydarpasa Teaching Hospital, Department of Obstetrics and Gynecology, Unit of Perinatology, Turkey.
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MeSH Terms
Biological Markers / blood
Chorionic Gonadotropin, beta Subunit, Human / blood*
Cohort Studies
Down Syndrome / blood*,  diagnosis
Pregnancy Trimester, First
Pregnancy-Associated Plasma Protein-A / analysis
Prenatal Diagnosis*
Retrospective Studies
Rh-Hr Blood-Group System / blood*
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Rh-Hr Blood-Group System; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

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