Document Detail

First-trimester screening for Down syndrome in singleton pregnancies achieved by intrauterine insemination.
MedLine Citation:
PMID:  12948096     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate whether achieving a singleton pregnancy by IUI affects the results of first-trimester screening for Down syndrome compared to naturally conceived pregnancy.
METHODS: Forty-nine IUI and 3059 naturally conceived singleton pregnancies were included in the study. Ovulation in IUI pregnancies was induced by clomiphene and human menopausal gonadotropin. Progesterone was given after insemination for 2 weeks. Down syndrome screening was performed using a combination of maternal age, fetal nuchal translucency, and maternal serum concentrations of free beta-hCG and PAPP-A during the period of 10-14 weeks' gestation.
RESULTS: In IUI pregnancies, nuchal translucency thickness and the levels of PAPP-A were significantly higher. The values of free beta-hCG were not statistically different between the two groups. The screen-positive rate in IUI pregnancies was significantly higher (14.3% vs. 7.1%).
CONCLUSIONS: Singleton pregnancies achieved by IUI have a higher screen-positive rate. Not only elder maternal age but also exogenous hormones given during the process of ovulation induction and after conception may play an important factor influencing positive screening results.
Tsung-Hsuan Lai; Su-Chee Chen; Ming-Song Tsai; Fa-Kung Lee; Chi-Feng Wei
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  20     ISSN:  1058-0468     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-09-01     Completed Date:  2004-03-30     Revised Date:  2013-03-14    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  327-31     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Taipei Medical Center, Cathay General Hospital, Taipei, Taiwan.
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MeSH Terms
Body Weight
Down Syndrome / diagnosis*
Genetic Testing*
Insemination, Artificial*
Maternal Age
Pregnancy Trimester, First
Prenatal Diagnosis*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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