| First-trimester prediction of preterm birth using ADAM12, PAPP-A, uterine artery Doppler, and maternal characteristics. | |
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MedLine Citation:
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PMID: 22847849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of this study was to estimate the efficiency of first-trimester a disintegrin and metalloprotease 12 (ADAM12), pregnancy-associated plasma protein A (PAPP-A), uterine artery Doppler, and maternal characteristics in the prediction of preterm birth (PTB). METHODS: This was a prospective cohort study of patients presenting for first-trimester aneuploidy screening. Maternal serum ADAM12 and PAPP-A levels were measured by immunoassay, and mean uterine artery Doppler pulsatility indices were calculated. The primary outcome was PTB <34 weeks' gestation, and the secondary outcome was PTB <37 weeks' gestation. Logistic regression was used to model the prediction of PTB using ADAM12, PAPP-A, uterine artery Doppler, and maternal characteristics, individually and in combination. Sensitivity, specificity, and area under the receiver-operating characteristic curves were compared between models. RESULTS: Of 578 patients, 36 (6.2%) delivered <34 weeks, and 78 (13.5%) delivered <37 weeks. For a 20% fixed false positive rate, ADAM12, PAPP-A, and uterine artery Doppler identified 58%, 52%, and 62% of patients with PTB <34 weeks and 42%, 48%, and 50% of patients with PTB <37 weeks, respectively. Combining these first-trimester parameters did not improve the predictive efficiency of the models. CONCLUSION: First-trimester ADAM12, PAPP-A, and uterine artery Doppler are each modestly predictive of PTB; however, combinations of these parameters do not further improve their screening efficiency. |
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Authors:
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Katherine R Goetzinger; Alison G Cahill; Janet Kemna; Linda Odibo; George A Macones; Anthony O Odibo |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-07-31 |
Journal Detail:
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Title: Prenatal diagnosis Volume: 32 ISSN: 1097-0223 ISO Abbreviation: Prenat. Diagn. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-02 Completed Date: 2013-03-04 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 1002-7 Citation Subset: IM |
Copyright Information:
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© 2012 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Obstetrics & Gynecology, Washington University in St. Louis, St. Louis, MO, USA. goetzingerk@wudosis.wustl.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ADAM Proteins
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blood* Adult African Americans Body Mass Index Cohort Studies False Positive Reactions Female Gestational Age* Humans Maternal Age Membrane Proteins / blood* Pregnancy Pregnancy Complications Pregnancy Trimester, First Pregnancy-Associated Plasma Protein-A / analysis* Premature Birth / diagnosis*, ethnology Prenatal Diagnosis / methods* Prospective Studies Pulsatile Flow ROC Curve Sensitivity and Specificity Uterine Artery / ultrasonography* |
| Grant Support | |
ID/Acronym/Agency:
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5T32 HD055172/HD/NICHD NIH HHS; UL1 RR024992/RR/NCRR NIH HHS; UL1 TR000448//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Membrane Proteins; EC 3.4.24.-/ADAM 12 protein; EC 3.4.24.-/ADAM Proteins; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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