Document Detail

First-trimester placental protein 13 screening for preeclampsia and intrauterine growth restriction.
MedLine Citation:
PMID:  17618748     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to evaluate first-trimester serum placental protein 13 (PP13) as a screening test for preeclampsia and intrauterine growth restriction (IUGR). STUDY DESIGN: We performed a prospective, nested case-control study in the Massachusetts General Hospital Obstetric Maternal Study. PP13 was measured by solid-phase sandwich enzyme-linked immunosorbent assay in serum samples that were collected at the first prenatal visit (9-12 weeks of gestation) from women who subsequently experienced preeclampsia (n = 47), IUGR (n = 42), or preterm delivery (n = 46). Women with uncomplicated term deliveries served as control subjects (n = 290) and were matched to cases by gestational age when serum was collected and for the duration of specimen storage. RESULTS: The median first-trimester PP13 level was 132.5 pg/mL in the control subjects. Median PP13 levels were significantly lower among women who had preeclampsia (27.2 pg/mL; P < .001), IUGR (86.6 pg/mL; P < .001), and preterm delivery (84.9 pg/mL; P = .007). When PP13 was expressed as multiples of the gestational age-specific medians among the control subjects, the multiples of the medians were 0.2 for preeclampsia, 0.6 for IUGR, and 0.6 for preterm delivery (P < .001 for each disorder compared with control subjects). Receiver operating characteristic analysis yielded areas under the curve of 0.91, 0.65, and 0.60 for preeclampsia, IUGR, and preterm delivery, respectively. At a 90% specificity rate, the corresponding sensitivities were 79%, 33%, and 28%, respectively. CONCLUSION: The screening of maternal PP13 levels in the first trimester is a promising diagnostic tool for the prediction of preeclampsia with high sensitivity and specificity.
Ilana Chafetz; Ido Kuhnreich; Marei Sammar; Yossi Tal; Yair Gibor; Hamutal Meiri; Howard Cuckle; Myles Wolf
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  197     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-09     Completed Date:  2007-09-06     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  35.e1-7     Citation Subset:  AIM; IM    
Diagnostic Technologies Ltd, Haifa, Israel.
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MeSH Terms
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Fetal Growth Retardation / blood,  diagnosis*
Galectins / biosynthesis,  blood*
Gestational Age
Obstetric Labor, Premature
Placenta / metabolism
Pre-Eclampsia / blood,  diagnosis*
Predictive Value of Tests
Pregnancy Proteins / biosynthesis,  blood*
Pregnancy Trimester, First
Prospective Studies
Sensitivity and Specificity
Grant Support
Reg. No./Substance:
0/Galectins; 0/LGALS13 protein, human; 0/Pregnancy Proteins

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