| First-trimester placental growth factor as a marker for hypertensive disorders and SGA. | |
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MedLine Citation:
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PMID: 20509158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of this study was to examine first-trimester maternal serum placental growth factor (PlGF) levels in pregnancies which later develop hypertensive and growth complications. METHODS: In this case-control study, PlGF levels were measured by AutoDELFIA immunoassay platform. There were 47 cases of at least one of the following adverse outcomes: pre-eclampsia (PE), small for gestational age (SGA), haemolysis elevated liver enzymes and low platelets (HELLP) and gestational hypertension (GH) and 452 matched controls. RESULTS: PlGF levels were significantly lower in cases of all PE, early PE, HELLP, all SGA, early SGA and SGA without PE, but not in GH, late PE, late SGA, PE with SGA or PE without SGA or HELLP. CONCLUSION: Low levels of first-trimester PlGF provide a good indicator of SGA complications and some hypertensive disorders, in particular severe cases of PE such as early onset and HELLP syndrome. |
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Authors:
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N J Cowans; A Stamatopoulou; E Matwejew; C S von Kaisenberg; K Spencer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Prenatal diagnosis Volume: 30 ISSN: 1097-0223 ISO Abbreviation: Prenat. Diagn. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-28 Completed Date: 2010-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 565-70 Citation Subset: IM |
Affiliation:
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Prenatal Research Unit, Clinical Biochemistry Department, King George Hospital, Goodmayes IG3 8YB, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / analysis, blood Case-Control Studies Female Fetal Growth Retardation / blood, diagnosis* Gestational Age Humans Hypertension, Pregnancy-Induced / blood, diagnosis* Infant, Newborn Infant, Small for Gestational Age* / blood Models, Biological Pregnancy Pregnancy Outcome Pregnancy Proteins / analysis*, blood Pregnancy Trimester, First / blood* Prenatal Diagnosis / methods Prognosis |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Pregnancy Proteins; 144589-93-5/placenta growth factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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