Document Detail

First-trimester placental growth factor as a marker for hypertensive disorders and SGA.
MedLine Citation:
PMID:  20509158     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of this study was to examine first-trimester maternal serum placental growth factor (PlGF) levels in pregnancies which later develop hypertensive and growth complications. METHODS: In this case-control study, PlGF levels were measured by AutoDELFIA immunoassay platform. There were 47 cases of at least one of the following adverse outcomes: pre-eclampsia (PE), small for gestational age (SGA), haemolysis elevated liver enzymes and low platelets (HELLP) and gestational hypertension (GH) and 452 matched controls. RESULTS: PlGF levels were significantly lower in cases of all PE, early PE, HELLP, all SGA, early SGA and SGA without PE, but not in GH, late PE, late SGA, PE with SGA or PE without SGA or HELLP. CONCLUSION: Low levels of first-trimester PlGF provide a good indicator of SGA complications and some hypertensive disorders, in particular severe cases of PE such as early onset and HELLP syndrome.
N J Cowans; A Stamatopoulou; E Matwejew; C S von Kaisenberg; K Spencer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  30     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-28     Completed Date:  2010-09-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  565-70     Citation Subset:  IM    
Prenatal Research Unit, Clinical Biochemistry Department, King George Hospital, Goodmayes IG3 8YB, UK.
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MeSH Terms
Biological Markers / analysis,  blood
Case-Control Studies
Fetal Growth Retardation / blood,  diagnosis*
Gestational Age
Hypertension, Pregnancy-Induced / blood,  diagnosis*
Infant, Newborn
Infant, Small for Gestational Age* / blood
Models, Biological
Pregnancy Outcome
Pregnancy Proteins / analysis*,  blood
Pregnancy Trimester, First / blood*
Prenatal Diagnosis / methods
Reg. No./Substance:
0/Biological Markers; 0/Pregnancy Proteins; 144589-93-5/placenta growth factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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