Document Detail

First-trimester nuchal translucency, nasal bones, and trisomy 21 in selected and unselected populations.
MedLine Citation:
PMID:  16522420     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to assess the role of fetal nasal bones evaluation in first-trimester screening for trisomy 21 in selected and unselected pregnancies. STUDY DESIGN: Visualization of the nasal bones was attempted in women attending for routine nuchal translucency screening (unselected population, n = 7116, 12 cases of trisomy 21), as well as in high-risk pregnancies referred to our tertiary care center (selected population, n = 510, 23 cases of trisomy 21). RESULTS: The sensitivity, specificity, positive and negative predictive value of absent nasal bones for trisomy 21 were 16.7%, 97.3%, 1.1%, 99.8% and 47.6%, 95.3%, 33.3%, 97.4% in the unselected and selected population, respectively. At logistic regression analysis including nuchal translucency and nasal bones findings, the latter resulted to be an independent predictor of trisomy 21 in the selected but not in the unselected population. CONCLUSION: First-trimester nasal bones assessment for trisomy 21 screening has a very different performance in selected and unselected pregnancies.
Federico Prefumo; Shanthi Sairam; Amarnath Bhide; Baskaran Thilaganathan
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  194     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-08     Completed Date:  2006-05-16     Revised Date:  2007-03-08    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  828-33     Citation Subset:  AIM; IM    
Division of Obstetrics and Gynaecology, St George's, University of London, United Kingdom.
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MeSH Terms
Down Syndrome / ultrasonography*
Middle Aged
Nasal Bone / ultrasonography*
Neck / ultrasonography*
Pregnancy Trimester, First
Prospective Studies
Sensitivity and Specificity
Ultrasonography, Prenatal*
Comment In:
Am J Obstet Gynecol. 2007 Jan;196(1):e19   [PMID:  16996461 ]

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