Document Detail

First trimester maternal serum placental growth factor in trisomy 21 pregnancies.
MedLine Citation:
PMID:  20301202     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine placental growth factor (PlGF) levels in first trimester maternal serum in trisomy 21 pregnancies and to investigate the potential value of PlGF in a first trimester screening test. METHODS: First trimester maternal serum from 70 trisomy 21 cases and 375 euploid controls were retrospectively analyzed for PlGF using a DELFIA Xpress immunoassay platform. Results were expressed as multiples of medians (MoM) for comparison. RESULTS: PlGF levels were significantly decreased in pregnancies with trisomy 21, 0.76 MoM versus 0.98 MoM in controls. Inclusion of PlGF into the first trimester combined test [maternal age, pregnancy associated plasma protein-A (PAPP-A), free-beta human chorionic gonadotrophin (beta-hCG) and nuchal translucency] would increase the detection rate by 0.5% at a 5% false positive rate. CONCLUSION: PlGF at 11 weeks to 13 weeks 6 days has the potential to be included as a marker for the detection of pregnancies with trisomy 21.
N J Cowans; A Stamatopoulou; K Spencer
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  30     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-04     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  449-53     Citation Subset:  IM    
Prenatal Research Unit, Clinical Biochemistry Department, King George Hospital, Goodmayes, UK.
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MeSH Terms
Biological Markers / blood
Chorionic Gonadotropin, beta Subunit, Human / blood
Down Syndrome / blood*,  ultrasonography
Gestational Age
Maternal Age
Middle Aged
Nuchal Translucency Measurement
Pregnancy Proteins / blood*
Pregnancy Trimester, First / blood*
Pregnancy-Associated Plasma Protein-A / analysis
Retrospective Studies
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Pregnancy Proteins; 144589-93-5/placenta growth factor; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

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