Document Detail

First-trimester maternal serum PP13 in the risk assessment for preeclampsia.
MedLine Citation:
PMID:  18539259     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of the study was to determine whether first-trimester maternal serum placental protein 13 (PP13) concentrations can be used in the risk assessment for preeclampsia.
STUDY DESIGN: This case-control study included 50 patients with preeclampsia and 250 patients with normal pregnancies. Samples were collected between 8 and 13 weeks of gestation. Serum PP13 concentrations were measured by immunoassay and expressed as medians and multiples of the median (MoM) for gestational age. Sensitivity and specificity were derived from receiver-operating characteristic curve analysis.
RESULTS: (1) Serum PP13 concentration in the first trimester was significantly lower in patients who developed preterm and early-onset preeclampsia than in those with normal pregnancies; and (2) at 80% specificity, a cutoff of 0.39 MoM had a sensitivity of 100% for early-onset preeclampsia and 85% for preterm preeclampsia.
CONCLUSION: Maternal serum first-trimester PP13 appears to be a reasonable marker for risk assessment for preterm preeclampsia but a weak marker for severe preeclampsia at term, and ineffective for identifying mild preeclampsia at term.
Roberto Romero; Juan Pedro Kusanovic; Nandor Gabor Than; Offer Erez; Francesca Gotsch; Jimmy Espinoza; Samuel Edwin; Ilana Chefetz; Ricardo Gomez; Jyh Kae Nien; Marei Sammar; Beth Pineles; Sonia S Hassan; Hamutal Meiri; Yossi Tal; Ido Kuhnreich; Zoltan Papp; Howard S Cuckle
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2008-06-09
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  199     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-04     Completed Date:  2008-08-29     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  122.e1-122.e11     Citation Subset:  AIM; IM    
Department of Health and Human Services, Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
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MeSH Terms
Area Under Curve
Biological Markers / blood*
Case-Control Studies
Oligopeptides / blood*
Pre-Eclampsia / blood*,  epidemiology*
Predictive Value of Tests
Pregnancy Outcome
Pregnancy Trimester, First / blood*
Pregnancy, High-Risk / blood*
ROC Curve
Grant Support
Z01 HD002400-16/HD/NICHD NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Oligopeptides; 0/PPi3 penicillopepsin

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