| First trimester maternal serum PIGF, free β-hCG, PAPP-A, PP-13, uterine artery Doppler and maternal history for the prediction of preeclampsia. | |
| | |
MedLine Citation:
|
PMID: 22459245 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate the detection of pregnancy hypertensive disorders by integrating maternal history, serum biomarkers and uterine artery Doppler in the first trimester. METHODS: We prospectively recruited 2118 women that underwent an 11-13 weeks aneuploidy screening. We gathered information on maternal history, uterine artery Doppler and serum biomarkers (PAPP-A, PlGF, PP-13 and free β-hCG). Models were developed for the prediction of overall preeclampsia (PE), early-onset PE, late-onset PE and gestational hypertension (GH). For each outcome, we performed a multivariate logistic regression starting from the saturated model: adopting a step-down procedure we excluded all factors not statistically significant (p > 0.05). Sensitivity models only for statistically significant parameters were calculated from the ROC curves for fixed false-positive rates (FPR). RESULTS: Among 2118 women, 46 (2.17%) developed GH and 25 (1.18%) were diagnosed with PE, including 12 (0.57%) early-onset PE and 13 (0.61%) late-onset PE. For a fixed FPR of 10 and 5%, serum PlGF, free β-hCG and chronic hypertension identified respectively 67 and 75% of women who developed early-onset PE. In the model for the prediction of overall PE the combination of the uterine artery Doppler pulsatility index (UtA PI) with PlGF and chronic hypertension reached a sensitivity of 60% for a 20% of FPR. CONCLUSION: An integration of maternal characteristics and first trimester maternal serum biomarkers (free β-hCG and PlGF) provided a possible screening for early-onset PE. In the overall PE model, UtA PI turned out to be statistically significant but did not improve the detection rate. |
| | |
Authors:
|
G Di Lorenzo; M Ceccarello; V Cecotti; L Ronfani; L Monasta; L Vecchi Brumatti; M Montico; G D'Ottavio |
Related Documents
:
|
18982815 - Pattern and outcome of antenatal care among women attending a catholic mission hospital... 15159645 - The resource mothers study of maternal phenylketonuria: preliminary findings. 15463805 - Effects of pregnancy on health: certain aspects of importance for women with cystic fib... 12236665 - Unintended pregnancy in a commercially insured population. 16272815 - Longitudinal variance of fat mass deposition during pregnancy evaluated by ultrasonogra... 9557825 - First established pregnancy after controlled ovarian hyperstimulation with recombinant ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-3-27 |
Journal Detail:
|
Title: Placenta Volume: - ISSN: 1532-3102 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-3-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8006349 Medline TA: Placenta Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
|
University of Trieste, Trieste, Italy; Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Associations of plasma von Willebrand factor ristocetin cofactor activity and 5-hydroxyindole acetic...
Next Document: Environmental proteomics, biodiversity statistics and food-web structure.