| First trimester maternal concentrations of thrombin-inhibitor complexes and the presence of histologic placental lesions at delivery. | |
| | |
MedLine Citation:
|
PMID: 19658036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Placental fetal vessel thrombosis or vasculitis and retroplacental hematoma have been associated with adverse neonatal outcomes. The activation of thrombin may contribute to the development of thrombosis and inflammation, and can be assessed through the measurement of thrombin-inhibitor complexes. METHODS: A nested case-control study was performed within a cohort of women with singleton gestations. Thrombin-antithrombin III (TAT) and Thrombin-Heparin co-factor II (T-HCII) concentrations were measured in first trimester maternal plasma. Cases were defined by retroplacental hematoma and/or fetal vessel thrombosis or vasculitis in the umbilical cord or chorionic plate. Outcomes were analysed with Mann-Whitney U and linear regression. RESULTS: Concentrations of both TAT (p = 0.013) and T-HCII (p = 0.001) from maternal plasma was significantly lower in cases than in controls. CONCLUSIONS: The development of placental inflammatory and thrombotic lesions at term may be associated with lower concentrations of thrombin-inhibitor complexes earlier in the pregnancy. |
| | |
Authors:
|
David N Hackney; Jye-Ping Chiao; Trevor A Macpherson; Hyagriv N Simhan |
Related Documents
:
|
15695986 - Severe fetal placental vascular lesions in term infants with neurologic impairment. 17535086 - Microscopic chorionic pseudocysts in placental membranes: a histologic lesion of in ute... 9422236 - Placental insights into neurodevelopmental and other childhood diseases. 1773876 - Vasoconstrictive effect of bile acids on isolated human placental chorionic veins. 9479536 - Comparative investigations on water-soluble crystallins of the embryonic, fetal, and po... 10101436 - Traditional medicine in nigeria and modern obstetric practice: need for cooperation. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 22 ISSN: 1476-4954 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-11-10 Completed Date: 2010-02-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: England |
Other Details:
|
Languages: eng Pagination: 837-42 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. dhackney@mail.magee.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antithrombin III Case-Control Studies Delivery, Obstetric Female Gestational Age Humans Inflammation / blood, diagnosis, epidemiology Mothers Osmolar Concentration Peptide Hydrolases / blood* Placenta Diseases / blood, diagnosis*, epidemiology Pregnancy Pregnancy Complications / blood, diagnosis, epidemiology Pregnancy Trimester, First / blood* Thrombosis / blood, diagnosis, epidemiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
R01 HD052732/HD/NICHD NIH HHS; R01 HD41663/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/antithrombin III-protease complex; 9000-94-6/Antithrombin III; EC 3.4.-/Peptide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Optimal laboratory panel for predicting preeclampsia.
Next Document: A case of transient hyperammonemia in the newborn transient neonatal hyperammonemia.