Document Detail

First trimester maternal concentrations of thrombin-inhibitor complexes and the presence of histologic placental lesions at delivery.
MedLine Citation:
PMID:  19658036     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Placental fetal vessel thrombosis or vasculitis and retroplacental hematoma have been associated with adverse neonatal outcomes. The activation of thrombin may contribute to the development of thrombosis and inflammation, and can be assessed through the measurement of thrombin-inhibitor complexes. METHODS: A nested case-control study was performed within a cohort of women with singleton gestations. Thrombin-antithrombin III (TAT) and Thrombin-Heparin co-factor II (T-HCII) concentrations were measured in first trimester maternal plasma. Cases were defined by retroplacental hematoma and/or fetal vessel thrombosis or vasculitis in the umbilical cord or chorionic plate. Outcomes were analysed with Mann-Whitney U and linear regression. RESULTS: Concentrations of both TAT (p = 0.013) and T-HCII (p = 0.001) from maternal plasma was significantly lower in cases than in controls. CONCLUSIONS: The development of placental inflammatory and thrombotic lesions at term may be associated with lower concentrations of thrombin-inhibitor complexes earlier in the pregnancy.
David N Hackney; Jye-Ping Chiao; Trevor A Macpherson; Hyagriv N Simhan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  22     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-11-10     Completed Date:  2010-02-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  837-42     Citation Subset:  IM    
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
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MeSH Terms
Antithrombin III
Case-Control Studies
Delivery, Obstetric
Gestational Age
Inflammation / blood,  diagnosis,  epidemiology
Osmolar Concentration
Peptide Hydrolases / blood*
Placenta Diseases / blood,  diagnosis*,  epidemiology
Pregnancy Complications / blood,  diagnosis,  epidemiology
Pregnancy Trimester, First / blood*
Thrombosis / blood,  diagnosis,  epidemiology
Young Adult
Grant Support
Reg. No./Substance:
0/antithrombin III-protease complex; 9000-94-6/Antithrombin III; EC 3.4.-/Peptide Hydrolases

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