Document Detail

First trimester malformation screening.
MedLine Citation:
PMID:  10428329     Owner:  NLM     Status:  MEDLINE    
First trimester fetal malformation screening still represents a diagnostic challenge in modem obstetrics. Being solely dependent on ultrasound instrumentation, and the skill and experience of the operator, recently improved by introducing high frequency transvaginal approach and digital image processing. This opens a new field of ultrasound in obstetrics called sonoembriology. Until now sonoembriology in routine clinical practice resulted in numerous reports about early detection of rare anomalies and uncommon syndromes. The reported sensitivity of sonoembriology with a respect to a final pregnancy outcome was more than 60% of all malformations in total, while in combination with ultrasound screening in second trimester, increases to in excess of 80%. The commonest anomalies detected by sonoembriology are anomalies of the head and brain, heart, abdominal wall, unbilical cord, urinary tract and skeleton. There is an important role of sonoembriology in the assessment of the nuchal translucency in the screening programme for chromosomal anomalies. This changes the well-known concept "fetus as a patient" to "embryo as a patient" and opens new frontiers in fetal diagnosis and therapy.
A Kurjak; S Kupesic; R Matijevic; M Kos; U Marton
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  85     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-08     Completed Date:  1999-09-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  93-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Medical School University of Zagreb, Sveti Duh Hospital, Zagreb, Croatia.
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MeSH Terms
Congenital Abnormalities / ultrasonography*
Gestational Age*
Pregnancy Outcome
Ultrasonography, Prenatal* / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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