| First-trimester fetal heart rate in mothers with opioid addiction. | |
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MedLine Citation:
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PMID: 20642509 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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AIM: To investigate the difference in fetal heart rate of opioid-dependent mothers compared to non-dependent mothers in the first trimester of pregnancy. DESIGN: The data of 74 consecutive singleton pregnancies of mothers enrolled in a maintenance programme for opioid-dependent women was matched to 74 non-exposed singleton pregnancies by maternal age, crown-rump length, smoking status, ethnic background and mode of conception. MEASUREMENT: Fetal heart rate measured as part of first-trimester screening by Doppler ultrasound between 11+0 and 13+6 gestational weeks was compared retrospectively. FINDINGS: The mean fetal heart rate in opioid-dependent mothers was 156.0 beats per minute (standard deviation 7.3) compared to 159.6 (6.5) in controls. The difference in fetal heart rate was significant (P = 0.02). There was a significant difference in mean maternal body mass index (P = 0.01) but not in mean nuchal translucency (P = 0.3), gestational age (0.5), fetal gender (P = 0.3) and parity (P = 0.3) between both groups. Fifty-five per cent (41 of 74) of cases were taking methadone, 30% (22 of 74) buprenorphine and 15% (11 of 74) were taking slow-release morphines throughout the pregnancy. CONCLUSIONS: In fetuses of opioid-dependent mothers a decreased fetal heart rate can already be observed between 11+0 and 13+6 gestational weeks. The effect of opioid intake needs to be taken into consideration when interpreting fetal heart rate in opioid-dependent mothers at first-trimester screening. |
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Authors:
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Maximilian Schmid; Lorenz Kuessel; Katharina Klein; Verena Metz; Gabriele Fischer; Elisabeth Krampl-Bettelheim |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Addiction (Abingdon, England) Volume: 105 ISSN: 1360-0443 ISO Abbreviation: Addiction Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9304118 Medline TA: Addiction Country: England |
Other Details:
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Languages: eng Pagination: 1265-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, A-1090 Vienna, Austria. maximilian.schmid@meduniwien.ac.at |
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R01 DA018417/DA/NIDA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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