Document Detail


First-trimester exposure to amoxycillin/clavulanic acid: a prospective, controlled study.
MedLine Citation:
PMID:  15327589     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: The number of published studies on the use of amoxycillin/clavulanic acid during pregnancy is small and so is the number of pregnancies investigated in those studies. In this study we wished to investigate prospectively the safety of intrauterine exposure to amoxycillin/clavulanic acid in a relatively large cohort of women. METHODS: Women treated (n = 191) with amoxycillin/clavulanic acid during the first trimester of pregnancy were recruited from two teratogen information centres in Israel. Exposed women were matched for age, smoking habits and alcohol consumption with 191 controls exposed to amoxycillin only for similar medical indications. RESULTS: Maternal age, birth weight, gestational age at delivery, rates of live births and abortions were comparable between the two groups. Rates of major malformations in the amoxycillin/clavulanic acid group (3/158, 1.9%) did not differ significantly from controls (5/163, 3%) (P = 0.49, relative risk = 0.62, 95% confidence interval 0.15, 2.55), and were within the expected baseline risk for the general population. CONCLUSION: These data suggest that exposure to amoxycillin/clavulanic acid during pregnancy is unlikely to be associated with an increased risk of malformations.
Authors:
Matitiahu Berkovitch; Orna Diav-Citrin; Revital Greenberg; Michal Cohen; Mordechai Bulkowstein; Svetlana Shechtman; Oxana Bortnik; Judy Arnon; Asher Ornoy
Related Documents :
7218129 - An mmpi typology of male alcoholics: admission, discharge and outcome comparisons.
10823349 - Hypoalgesic effect of millimeter waves in mice: dependence on the site of exposure.
9125619 - Cocaine's lethality increases during late gestation in the rat: a study of "critical pe...
22977029 - Mr imaging findings of ectopic pregnancy: a pictorial review.
19822399 - Apoptosis may involve in prenatally heroin exposed neurobehavioral teratogenicity?
9046369 - Effects of acute prenatal ethanol administration in a reciprocal cross of c57bl/6j and ...
20544819 - The impact of miscarriage and parity on patterns of maternal distress in pregnancy.
19561889 - Spontaneous pneumothorax: an unusual complication of pregnancy--a case report and revie...
8180289 - Effects on navajo birthrate from loss of the intrauterine device.
Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  58     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-25     Completed Date:  2004-12-17     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  298-302     Citation Subset:  IM    
Affiliation:
Clinical Pharmacology and Toxicology unit, Drug Consultation Centre, Assaf Harofeh Medical Centre, Zerifin, Israel. mberkovitch@asaf.health.gov.il
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amoxicillin / adverse effects*
Anti-Bacterial Agents / adverse effects*
Case-Control Studies
Clavulanic Acid / adverse effects*
Cohort Studies
Female
Humans
Infant, Newborn
Pregnancy
Pregnancy Complications, Infectious / drug therapy*
Pregnancy Outcome
Pregnancy Trimester, First
Prospective Studies
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 26787-78-0/Amoxicillin; 58001-44-8/Clavulanic Acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A convenient five-drug cocktail for the assessment of major drug metabolizing enzymes: a pilot study...
Next Document:  Statins and newly diagnosed diabetes.