Document Detail

First trimester diagnosis of partial mole.
MedLine Citation:
PMID:  15875207     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Partial mole is one of the two distinctive subtypes of hydatidiform mole. It is usually paternally derived triploid conceptions in which embryonal development occurs in association with trophoblastic hyperplasia. The definite diagnosis is confirmed by pathological and cytogenetic studies. Ultrasound might be helpful to diagnose partial mole in the first trimester. CASE: A 25-year-old woman, gravida 2, para 0-0-1-0, was initially seen for antenatal care at 6 weeks' pregnant. Ultrasound was undertaken at 13 weeks' pregnancy due to her first fetal anomaly, which demonstrated partial mole and embryonic death. The serum beta hCG was 190,900 mIU/ml. Suction curettage was performed without complication. Histopathological study confirmed partial mole and cytogenetic study of the placenta revealed an uncommon karyotype, mosaicism of triploid (69,XXX/69,XXY). Serum beta hCG was declined and negative at 8 weeks. The patient was well and serum beta hCG remained normal throughout 6 months of follow-up. CONCLUSION: Although the majority of partial mole pregnancies cannot be detected by routine first trimester ultrasound examination, first trimester ultrasound can be helpful in some cases, such as this one. If partial mole is sonographically suspected, it should be confirmed with histopathology and cytogenetic studies. The management is similar to complete mole including prompt evacuation and careful monitoring of beta hCG.
Vorapong Phupong; Surang Triratanachat; Chinnavorn Promchainant; Pornthip Ultchaswadi
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-05-04
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  272     ISSN:  0932-0067     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-27     Completed Date:  2006-03-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  235-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Rama IV Road, Pathumwan, Bangkok 10330, Thailand.
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MeSH Terms
Chorionic Gonadotropin, beta Subunit, Human / blood
Chromosome Aberrations
Fetal Death
Fetus / abnormalities
Gestational Age
Hydatidiform Mole / blood,  diagnosis*
Pregnancy Trimester, First*
Sex Chromosome Aberrations
Ultrasonography, Prenatal
Uterine Neoplasms / blood,  diagnosis*
Reg. No./Substance:
0/Chorionic Gonadotropin, beta Subunit, Human

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