Document Detail

First trimester crown-rump length and embryonic volume of aneuploid fetuses measured in Virtual Reality.
MedLine Citation:
PMID:  23225608     Owner:  NLM     Status:  Publisher    
Introduction: Aneuploidy is associated with fetal growth restriction already present from the first trimester of pregnancy onwards. With three-dimensional (3D) ultrasound it is possible to measure Embryonic Volume (EV). The innovative 3D Virtual-Reality (VR) approach is a fast and reliable way to measure EV. The relative increase in EV is much larger than that of the CRL over the same time period. We examined whether EV is a better predictor of growth restriction in aneuploid fetuses. Methods: We retrospectively measured CRL and EV in prospectively collected 3D ultrasound volumes of 55 aneuploid fetuses in our Barco I-Space VR system. The gestational age (GA) ranged from 11(+2) to 14(+4) weeks. We compared our measured data with previous published reference curves of euploid fetuses. Delta-values were calculated by subtracting observed values from the expected mean of euploid fetuses of the same GA. The one-sample t-test was performed to test significance. Results: The CRL of fetuses with trisomy 21 (n = 26), trisomy 13 (n = 5) and monosomy X (n = 5) is comparable to those of euploid fetuses. In fetuses with trisomy 18 (n = 19) the CRL is 14.5% smaller (p<0.001). EV in fetuses with trisomy 21, 18, 13 and monosomy X is smaller (respectively -27.8% p<0.001, -39.4% p=<0.001, -40.9 p=0,004 and -27.3% p=0.055). Conclusion: When relying on CRL measurements alone, growth restriction is especially manifest in trisomy 18. Using EV, growth restriction is also evident in trisomy 21, 13 and monosomy X. EV seems to be a more precise parameter to assess first trimester growth restriction in aneuploid fetuses. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
L Baken; Pnacm van Heesch; Hij Wildschut; Ahj Koning; Pj van der Spek; Eap Steegers; N Exalto
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-5
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands.
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