| First-trimester combined screening for trisomy 21 in a predominantly Chinese population. | |
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MedLine Citation:
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PMID: 17171632 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine the effectiveness of first-trimester fetal trisomy 21 screening using a combination of maternal age, nuchal translucency thickness (NT) and maternal serum free beta-human chorionic gonadotropin (beta-hCG) and pregnancy-associated plasma protein-A (PAPP-A) levels in a predominantly Chinese population in Hong Kong. METHODS: This was a prospective study over a 1.5-year period of 2990 women who underwent combined screening for trisomy 21 between 11+0 and 13+6 weeks of gestation in a university fetal medicine unit. NT was measured according to the criteria set by The Fetal Medicine Foundation (FMF), maternal serum free beta-hCG and PAPP-A levels were measured, and the risk of trisomy 21 was calculated using The FMF's algorithm. Fetal karyotyping was advised when the risk was 1 : 300 or above. All subjects were followed up for pregnancy and fetal outcome. RESULTS: Of the 2990 women who underwent the screening program, 99% were Chinese. There were 57 twin pregnancies, giving a total of 3047 fetuses. Thirty-one percent of the women were 35 years old or above. One hundred and eighty-five (6.1%) fetuses were screen-positive; this included 14 cases of trisomy 21 and 17 cases of other chromosomal abnormalities. The positive predictive value was 16.7%. Among the 2862 screen-negative fetuses, only 18 (0.6%) cases had an unknown fetal outcome. There were no cases in which trisomy 21 was missed and the infant was liveborn. CONCLUSION: First-trimester combined screening for fetal trisomy 21 is highly effective among Chinese subjects. |
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Authors:
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T Y Leung; L W Chan; T N Leung; T Y Fung; D S Sahota; K Spencer; T K Lau |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Volume: 29 ISSN: 0960-7692 ISO Abbreviation: Ultrasound Obstet Gynecol Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-09 Completed Date: 2007-10-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9108340 Medline TA: Ultrasound Obstet Gynecol Country: England |
Other Details:
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Languages: eng Pagination: 14-7 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2006 ISUOG. |
Affiliation:
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Department of Obstetrics and Gynecology, The Chinese University of Hong Kong, Hong Kong, China SAR, and Prenatal Screening Unit, Clinical Biochemistry Department, Harold Wood Hospital, Essex, UK. tyleung@cuhk.edu.hk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Asian Continental Ancestry Group / ethnology Biological Markers / blood Chorionic Gonadotropin, beta Subunit, Human / blood* Down Syndrome / diagnosis*, ethnology, genetics Female Hong Kong / epidemiology Humans Nuchal Translucency Measurement Pregnancy Pregnancy Trimester, First Pregnancy-Associated Plasma Protein-A / analysis* Prenatal Diagnosis / methods* Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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