| First trimester biochemical screening for trisomy 21: the role of free beta hCG, alpha fetoprotein and pregnancy associated plasma protein A. | |
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MedLine Citation:
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PMID: 7530437 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The potential efficacy of screening for trisomy 21 in the first trimester, using maternal serum markers alpha fetoprotein, free beta human chorionic gonadotropin, unconjugated oestriol and pregnancy associated plasma protein A, was studied in an unselected population of women between the seventh and fourteenth week of gestation. Using a combination of alpha fetoprotein and free beta human chorionic gonadotropin, 53% of affected pregnancies could be identified at a false positive rate of 5%. Unconjugated oestriol and pregnancy associated plasma protein A levels were lower in cases of trisomy 21, but their inclusion with other markers did not significantly improve detection rate. Monitoring the same pregnancies also in the second trimester showed that screening in the first trimester identified the same cases as in the second. We conclude that first trimester screening using free beta human chorionic gonadotropin and alpha fetoprotein, is a viable possibility and will lead to detection rates in excess of 50%. Prospective studies are needed to confirm these observations. |
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Authors:
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K Spencer; D A Aitken; J A Crossley; G McCaw; E Berry; R Anderson; J M Connor; J N Macri |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Multicenter Study |
Journal Detail:
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Title: Annals of clinical biochemistry Volume: 31 ( Pt 5) ISSN: 0004-5632 ISO Abbreviation: Ann. Clin. Biochem. Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1995-02-21 Completed Date: 1995-02-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0324055 Medline TA: Ann Clin Biochem Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 447-54 Citation Subset: IM |
Affiliation:
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Clinical Biochemistry Department, Oldchurch Hospital, Romford, Essex, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Biological Markers / blood Blood Proteins / metabolism Chorionic Gonadotropin / blood* Chorionic Gonadotropin, beta Subunit, Human Down Syndrome / blood, diagnosis* Enzyme-Linked Immunosorbent Assay Estriol / blood False Positive Reactions Female Fetal Diseases / blood, diagnosis* Great Britain Humans Likelihood Functions Longitudinal Studies Peptide Fragments / blood* Predictive Value of Tests Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Second Pregnancy-Associated Plasma Protein-A / metabolism* Prenatal Diagnosis* ROC Curve Risk Factors alpha-Fetoproteins / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Proteins; 0/Chorionic Gonadotropin; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Peptide Fragments; 0/alpha-Fetoproteins; 50-27-1/Estriol; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A |
| Comments/Corrections | |
Comment In:
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Ann Clin Biochem. 1995 Sep;32 ( Pt 5):512-3
[PMID:
8830631
]
Ann Clin Biochem. 1995 Mar;32 ( Pt 2):233 [PMID: 7540382 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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