Document Detail

First-trimester biochemical screening for fetal chromosome abnormalities and neural tube defects.
MedLine Citation:
PMID:  8284287     Owner:  NLM     Status:  MEDLINE    
Alpha-fetoprotein (AFP), unconjugated oestriol (UE3), intact human chorionic gonadotrophin (intHCG), and the free beta subunit of chorionic gonadotrophin (F beta HCG) were investigated in a series of 21 chromosomally abnormal and 14 open neural tube defect pregnancies ascertained from a series of 14,000 prospectively collected maternal serum samples at 6-14 weeks' gestation. In 16 cases of Down's syndrome, significant reductions were found for AFP (0.65 multiples of the normal median) and UE3 (0.67 MOM). IntHCG levels were unaltered (0.97 MOM) but a significant increase was found for F beta HCG (1.96 MOM). Significant correlations were found for AFP and UE3 in the controls and for intHCG and F beta HCG in both the control and the Down's syndrome pregnancies. In a group of five trisomy 18 pregnancies, median MOMs were for AFP 0.71, for UE3 0.34, for intHCG 0.27, and for F beta HCG 0.15. None of 13 pregnancies with open neural tube defects at 8-13 weeks gestation had elevated maternal serum AFP levels, whereas matched second-trimester samples from the same pregnancies at 16-18 weeks gestation all had significantly elevated AFP levels. Thus, biochemical screening for chromosome abnormalities may be practicable in the first trimester using free beta human chorionic gonadotrophin in combination with AFP and maternal age. However, a separate screening protocol using AFP at 15-18 weeks gestation would still be required for effective detection of neural tube defects.
D A Aitken; G McCaw; J A Crossley; E Berry; J M Connor; K Spencer; J N Macri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  13     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1994-02-17     Completed Date:  1994-02-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  681-9     Citation Subset:  IM    
Duncan Guthrie Institute of Medical Genetics, Yorkhill, Glasgow, U.K.
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MeSH Terms
Biological Markers / blood
Chromosome Aberrations / diagnosis*
Chromosome Disorders
Embryonic and Fetal Development / genetics
Genetic Testing / methods*
Neural Tube Defects / diagnosis*
Pregnancy Proteins / blood*
Pregnancy Trimester, First
Prospective Studies
Reg. No./Substance:
0/Biological Markers; 0/Pregnancy Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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