Document Detail

First-trimester biochemical screening for Down syndrome with the use of PAPP-A, AFP, and beta-hCG.
MedLine Citation:
PMID:  8843997     Owner:  NLM     Status:  MEDLINE    
Biochemical screening for Down syndrome (DS) is well established in the second trimester of pregnancy, but there is little information available on its value in the first trimester. This study describes our preliminary results with biochemical screening for DS in the first trimester of pregnancy in order to evaluate its efficacy at this time. Our study population, including 19 DS pregnancies, was evaluated using maternal serum levels of alpha-fetoprotein (AFP), beta-human chorionic gonadotropin (beta-hCG), and pregnancy-associated plasma protein A (PAPP-A). At a false positive rate (FPR) of 5 per cent, the detection rate (DR) for DS is 9 per cent for beta-hCG, 18 per cent for AFP, and 66 per cent for PAPP-A when considering these parameters individually. With different combinations of the analytes, the best detection rates are obtained with the association of PAPP-A and AFP (85 and 82 per cent DR for a 10 and 5 per cent FPR, respectively). Our data support the value of first-trimester biochemical screening for DS and that of PAPP-A as a single marker.
E Casals; A Fortuny; J G Grudzinskas; Y Suzuki; B Teisner; C Comas; C Sanllehy; J Ojuel; A Borrell; A Soler; A M Ballesta
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  16     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-11-01     Completed Date:  1996-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  405-10     Citation Subset:  IM    
Clinical Biochemistry Laboratory, Hospital Clinic, University of Barcelona, Spain.
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MeSH Terms
Biological Markers
Chorionic Gonadotropin, beta Subunit, Human / blood*
Down Syndrome / diagnosis*
Fetal Diseases / diagnosis*
Fluorescent Antibody Technique
Pregnancy Trimester, First
Pregnancy-Associated Plasma Protein-A / analysis*
Prenatal Diagnosis / standards*,  statistics & numerical data
ROC Curve
Reagent Kits, Diagnostic
alpha-Fetoproteins / analysis*
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Reagent Kits, Diagnostic; 0/alpha-Fetoproteins; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

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