| First trimester biochemical screening for Down syndrome: free beta hCG versus intact hCG. | |
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MedLine Citation:
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PMID: 11038453 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To compare free beta hCG versus intact hCG in first trimester Down syndrome screening we analysed 63 cases of Down syndrome and 400 unaffected control pregnancies between 10 and 13 weeks' gestation. The Down syndrome median multiple of the median (MoM) was significantly higher (p=0.001) for free beta hCG (1.89 MoM) than for intact hCG (1.37 MoM). Although distributions for free beta hCG (unaffected, 0.2157; DS, 0.2322) are wider than for intact hCG (unaffected, 0.1697; DS, 0.2158), overall 27% of Down syndrome cases were above the 95th percentile for free beta hCG compared to 19% for intact hCG. Combined with maternal age, free beta hCG detected 45% of Down syndrome pregnancies at a 5% false positive rate. Intact hCG combined with maternal age demonstrated a detection efficiency comparable to maternal age alone (35% versus 32%). In contrast, a recent study (Haddow et al., 1998-NEJM 338: 955-961) indicated that intact hCG yielded a higher first trimester Down syndrome detection efficiency than free beta hCG (29% versus 25% respectively). Re-analysis of distribution parameters in the Haddow et al. study, however, show that free beta hCG was actually the better marker (23% detection for intact hCG versus 29% for free beta hCG). |
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Authors:
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T Hallahan; D Krantz; F Orlandi; C Rossi; P Curcio; S Macri; J Larsen; P Buchanan; J Macri |
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Publication Detail:
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Type: Journal Article; Meta-Analysis |
Journal Detail:
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Title: Prenatal diagnosis Volume: 20 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-11-08 Completed Date: 2000-12-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 785-9;discussion 790-1 Citation Subset: IM |
Copyright Information:
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Copyright 2000 John Wiley & Sons, Ltd. |
Affiliation:
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NTD Laboratories, Inc., Huntington Station, NY 11746, USA. NTDLabs@aol.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Chorionic Gonadotropin / blood Chorionic Gonadotropin, beta Subunit, Human / blood* Down Syndrome / blood, diagnosis* Enzyme-Linked Immunosorbent Assay Female Humans Mass Screening / methods*, standards Predictive Value of Tests Pregnancy Pregnancy Trimester, First Prenatal Diagnosis* |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Chorionic Gonadotropin, beta Subunit, Human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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