Document Detail


First trimester Plasmodium falciparum infections display a typical 'placental' phenotype.
MedLine Citation:
PMID:  23045626     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background. Plasmodium falciparum-infected erythrocytes (IE) adhere to host cell receptors allowing parasites to sequester in deep vascular beds of various organs. This defining phenomenon of malaria pathogenesis is key to the severe clinical complications associated with cerebral and placental malaria. The principal ligand associated with the binding to chondroitin sulfate A (CSA) that allows placental sequestration of IE is a P. falciparum erythrocyte membrane protein 1 (PfEMP1) family member encoded by the var2csa gene.Methods. Here, we investigated the transcription pattern of var genes by real-time PCR, the expression of VAR2CSA, protein by flow cytometry and the CSA-binding ability of IE collected at different stages of pregnancy using a static-based Petri dish assay.Results. Through comparison with the profiles of isolates from non-pregnant hosts, we report several lines of evidence showing that parasites infecting women during pregnancy preferentially express VAR2CSA protein, and that selection for the capacity to adhere to CSA via VAR2CSA expression occurs early in pregnancy.Conclusion. Our data thus suggest that the placental tropism of P. falciparum is already established in the first trimester of pregnancy, with consequent implications for the development of the pathology associated with placental malaria.
Authors:
Justin Doritchamou; Gwladys Bertin; Azizath Moussiliou; Pascal Bigey; Firmine Viwami; Sem Ezinmegnon; Nadine Fievet; Achille Massougbodji; Philippe Deloron; Nicaise Tuikue Ndam
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-8
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  -     ISSN:  1537-6613     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
PRES Sorbonne Paris Cité, Faculté de Pharmacie, Université Paris Descartes, France.
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