Document Detail


First trimester PTX3 levels in women who subsequently develop preeclampsia and fetal growth restriction.
MedLine Citation:
PMID:  19544202     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pentraxin 3 (PTX3) and C-reactive protein (CRP) levels were measured in the first trimester of pregnancy in women who subsequently developed preeclampsia (PE, n=16) and fetal growth restriction (FGR, n=12) requiring iatrogenic delivery before 37 weeks, and those who had uncomplicated pregnancies delivering at term (n=60). Mean PTX3 levels were significantly higher in women who subsequently developed PE (7.31 ng/ml, SD = 4.12) when compared to those with normal pregnancy outcome (4.92 ng/ml, SD = 1.94, p=0.0046). There were no significant differences between PTX3 levels in women with FGR (4.82 ng/ml, SD = 2.35) compared to normal pregnancy outcome (p=0.88). The median CRP levels did not vary significantly between the three groups (p=0.26). PTX3 levels in women who subsequently develop PE are already elevated in the first trimester, but not in those that develop FGR. This supports the hypothesis of an excessive maternal inflammatory response to pregnancy in the etiology of PE.
Authors:
Irene Cetin; Veronica Cozzi; Aris T Papageorghiou; Virginia Maina; Alessandro Montanelli; Cecilia Garlanda; Basky Thilaganathan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  88     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2009  
Date Detail:
Created Date:  2009-06-22     Completed Date:  2009-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  846-9     Citation Subset:  IM    
Affiliation:
Unit of Obstetrics and Gynecology I, Department of Clinical Sciences Luigi Sacco, University of Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
C-Reactive Protein / metabolism*
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Female
Fetal Growth Retardation / metabolism*
Humans
Pre-Eclampsia / metabolism*
Pregnancy
Pregnancy Outcome
Pregnancy Trimester, First*
Prospective Studies
Risk Factors
Serum Amyloid P-Component / metabolism*
Statistics, Nonparametric
Chemical
Reg. No./Substance:
0/Serum Amyloid P-Component; 148591-49-5/PTX3 protein; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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