Document Detail

First-time development of FVIII inhibitor in haemophilia patients during the postoperative period.
MedLine Citation:
PMID:  12410646     Owner:  NLM     Status:  MEDLINE    
Development of inhibitor to FVIII in haemophilia patients is well-known and is not uncommon. However, their development for the first time during the postoperative period has hardly been reported. In a developing country such as India, where resources are limited, development of such an eventuality may prove disastrous. However, as many of our patients are sparingly treated, therefore, even if they test negative for the inhibitor preoperatively, they may get the requisite FVIII antigenic stimulation during the preoperative and immediate postoperative period, leading to the development of inhibitors during this critical time of wound healing. We describe here six patients who developed such an inhibitor, from a group of 35 patients with haemophilia A who underwent various surgical procedures (19%). We stress that such an eventuality may not remain rare in developing countries as more patients of severe haemophilia undergo surgery and are therefore challenged for the first time in their life with large amounts of FVIII concentrate during their preoperative period.
K Ghosh; F Jijina; S Shetty; M Madkaikar; D Mohanty
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Haemophilia : the official journal of the World Federation of Hemophilia     Volume:  8     ISSN:  1351-8216     ISO Abbreviation:  Haemophilia     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-04     Completed Date:  2003-04-14     Revised Date:  2009-10-21    
Medline Journal Info:
Nlm Unique ID:  9442916     Medline TA:  Haemophilia     Country:  England    
Other Details:
Languages:  eng     Pagination:  776-80     Citation Subset:  IM    
Institute of Immunohaematology (ICMR), KEM Hospital, Parel, Mumbai, India.
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MeSH Terms
Developing Countries
Factor VIII / administration & dosage,  antagonists & inhibitors*
Hemophilia A / blood*,  complications
Length of Stay
Postoperative Hemorrhage / blood*,  etiology
Surgical Procedures, Operative
Reg. No./Substance:
9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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