Document Detail


First-time development of FVIII inhibitor in haemophilia patients during the postoperative period.
MedLine Citation:
PMID:  12410646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Development of inhibitor to FVIII in haemophilia patients is well-known and is not uncommon. However, their development for the first time during the postoperative period has hardly been reported. In a developing country such as India, where resources are limited, development of such an eventuality may prove disastrous. However, as many of our patients are sparingly treated, therefore, even if they test negative for the inhibitor preoperatively, they may get the requisite FVIII antigenic stimulation during the preoperative and immediate postoperative period, leading to the development of inhibitors during this critical time of wound healing. We describe here six patients who developed such an inhibitor, from a group of 35 patients with haemophilia A who underwent various surgical procedures (19%). We stress that such an eventuality may not remain rare in developing countries as more patients of severe haemophilia undergo surgery and are therefore challenged for the first time in their life with large amounts of FVIII concentrate during their preoperative period.
Authors:
K Ghosh; F Jijina; S Shetty; M Madkaikar; D Mohanty
Related Documents :
22349136 - Serum il-33 but not st2 level is elevated in intermittent allergic rhinitis and is a ma...
16678686 - Activated protein c-protein c inhibitor complex: a new biological marker for aortic ane...
20120676 - The prevalence of thrombophilia in idiopathic osteonecrosis of the hip.
7718166 - Haemostatic derangement in patients with intracranial tumours.
22285386 - Relationship of obesity to recanalization after hyperacute recombinant tissue-plasminog...
10544836 - Causes of death in korean patients with systemic lupus erythematosus: a single center r...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Haemophilia : the official journal of the World Federation of Hemophilia     Volume:  8     ISSN:  1351-8216     ISO Abbreviation:  Haemophilia     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-04     Completed Date:  2003-04-14     Revised Date:  2009-10-21    
Medline Journal Info:
Nlm Unique ID:  9442916     Medline TA:  Haemophilia     Country:  England    
Other Details:
Languages:  eng     Pagination:  776-80     Citation Subset:  IM    
Affiliation:
Institute of Immunohaematology (ICMR), KEM Hospital, Parel, Mumbai, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Developing Countries
Factor VIII / administration & dosage,  antagonists & inhibitors*
Hemophilia A / blood*,  complications
Humans
India
Length of Stay
Male
Postoperative Hemorrhage / blood*,  etiology
Surgical Procedures, Operative
Chemical
Reg. No./Substance:
9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Paradoxical hyperfibrinolysis is associated with a more intensely haemorrhagic phenotype in severe c...
Next Document:  Overall haemostatic potential can be used for estimation of thrombin-activatable fibrinolysis inhibi...