| First signal on the cryogenic Fourier-transform ion cyclotron resonance mass spectrometer. | |
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MedLine Citation:
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PMID: 17931882 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The construction and achievement of the first signal on a cryogenic Fourier-transform ion cyclotron resonance mass spectrometer (FTICR-MS) are reported here, demonstrating proof-of-concept of this new instrument design. Building the FTICR cell into the cold bore of a superconducting magnet provided advantages over conventional warm bore design. At 4.2 K, the vacuum system cryopumps itself, thus removing the requirement for a large bore to achieve the desired pumping speed for maintaining base pressure. Furthermore, because the bore diameter has been reduced, the amount of magnet wire needed to achieve high field and homogeneity was also reduced, greatly decreasing the cost/Tesla of the magnet. The current instrument implements an actively shielded 14-Tesla magnet of vertical design with an external matrix-assisted laser desorption/ionization (MALDI) source. The first signal was obtained by detecting the laser desorbed/ionized (LDI) C(60)(+*) ions, with the magnet at 7 Tesla, unshimmed, and the preamplifier mounted outside of the vacuum chamber at room temperature. A subsequent experiment done with the magnet at 14 Tesla and properly shimmed produced a C(60) spectrum showing approximately 350,000 resolving power at m/z approximately 720. Increased magnetic field strength improves many FTMS performance parameters simultaneously, particularly mass resolving power and accuracy. |
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Authors:
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Cheng Lin; Raman Mathur; Kostantin Aizikov; Peter B O'Connor |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-09-14 |
Journal Detail:
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Title: Journal of the American Society for Mass Spectrometry Volume: 18 ISSN: 1044-0305 ISO Abbreviation: J. Am. Soc. Mass Spectrom. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-06 Completed Date: 2008-01-30 Revised Date: 2010-09-14 |
Medline Journal Info:
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Nlm Unique ID: 9010412 Medline TA: J Am Soc Mass Spectrom Country: United States |
Other Details:
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Languages: eng Pagination: 2090-3 Citation Subset: IM |
Affiliation:
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Cardiovascular Proteomics Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cyclotrons* Fourier Analysis* Helium / chemistry Mass Spectrometry / methods* |
| Grant Support | |
ID/Acronym/Agency:
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P41 RR010888-080099/RR/NCRR NIH HHS; P41 RR010888-118035/RR/NCRR NIH HHS; P41RR-10888/RR/NCRR NIH HHS; R01 GM078293-02/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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7440-59-7/Helium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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