| First- and second-trimester thyroid hormone reference data in pregnant women: a FaSTER (First- and Second-Trimester Evaluation of Risk for aneuploidy) Research Consortium study. | |
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MedLine Citation:
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PMID: 18585522 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to calculate first and second trimester reference ranges and within-woman correlations for TSH, free T4, and thyroid antibodies. STUDY DESIGN: TSH, free T4, and thyroid antibodies were measured in paired sera from 9562 women in the FaSTER trial of Down syndrome screening. RESULTS: The median first trimester TSH (1.05 mIU/L) is lower than the second (1.23 mIU/L); and 98th centile is higher (4.15 vs 3.77 mIU/L). Within-woman paired TSH correlations are moderately strong (r(2) = 0.64). Among women with first trimester TSH values above the 98th centile, second trimester values are over the 95th centile in 68%. Median first trimester free T4 values (1.10 ng/dL) are higher than second (1.01 ng/dL). Paired free T4 measurements correlate weakly (r(2) = 0.23). Among women with first trimester free T4 values below the 2nd centile, second trimester values are below the 5th centile in 32%. Antibody measurements correlate strongly between trimesters (thyroperoxidase r(2) = 0.79, thyroglobulin r(2) = 0.83). CONCLUSION: TSH and free T4 measurements require gestation-specific reference ranges. |
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Authors:
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Geralyn Lambert-Messerlian; Monica McClain; James E Haddow; Glenn E Palomaki; Jacob A Canick; Jane Cleary-Goldman; Fergal D Malone; T Flint Porter; David A Nyberg; Peter Bernstein; Mary E D'Alton; |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 199 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-30 Completed Date: 2008-07-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 62.e1-6 Citation Subset: AIM; IM |
Affiliation:
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Warren Alpert Medical School of Brown University, Providence, RI, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autoantibodies / blood* Female Gestational Age Humans Pregnancy Pregnancy Trimester, First / blood Pregnancy Trimester, Second / blood Reference Values Thyrotropin / blood* Thyroxine / blood* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HD 38652/HD/NICHD NIH HHS; R01 HD038652-01/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/anti-thyroglobulin; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin |
| Investigator | |
Investigator/Affiliation:
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K Welch / ; R Denchy / ; R Ball / ; B Oshiro / ; L Cannon / ; K Nelson / ; C Loucks / ; A Yoshimura / ; D Luthy / ; S Coe / ; C Comstock / ; J Esler / ; R Bukowski / ; G Hankins / ; G Saade / ; J Lee / ; R Berkowitz / ; K Eddleman / ; Y Kharbutli / ; I Merkatz / ; S Carter / ; L Dugoff / ; J Hobbins / ; L Schultz / ; I Timor-Tritsch / ; M Paidas / ; J Borsuk / ; S Craigo / ; D Bianchi / ; B Isquith / ; B Berlin / ; S Carr / ; C Duquette / ; H Wolfe / ; R Baughman / ; J Hanson / ; F de la Cruz / ; K Dukes / ; T Tripp / ; D Emig / ; L Sullivan / |
| Comments/Corrections | |
Erratum In:
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Am J Obstet Gynecol. 2008 Sep;199(3):326 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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