Document Detail


First- and second-trimester thyroid hormone reference data in pregnant women: a FaSTER (First- and Second-Trimester Evaluation of Risk for aneuploidy) Research Consortium study.
MedLine Citation:
PMID:  18585522     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to calculate first and second trimester reference ranges and within-woman correlations for TSH, free T4, and thyroid antibodies. STUDY DESIGN: TSH, free T4, and thyroid antibodies were measured in paired sera from 9562 women in the FaSTER trial of Down syndrome screening. RESULTS: The median first trimester TSH (1.05 mIU/L) is lower than the second (1.23 mIU/L); and 98th centile is higher (4.15 vs 3.77 mIU/L). Within-woman paired TSH correlations are moderately strong (r(2) = 0.64). Among women with first trimester TSH values above the 98th centile, second trimester values are over the 95th centile in 68%. Median first trimester free T4 values (1.10 ng/dL) are higher than second (1.01 ng/dL). Paired free T4 measurements correlate weakly (r(2) = 0.23). Among women with first trimester free T4 values below the 2nd centile, second trimester values are below the 5th centile in 32%. Antibody measurements correlate strongly between trimesters (thyroperoxidase r(2) = 0.79, thyroglobulin r(2) = 0.83). CONCLUSION: TSH and free T4 measurements require gestation-specific reference ranges.
Authors:
Geralyn Lambert-Messerlian; Monica McClain; James E Haddow; Glenn E Palomaki; Jacob A Canick; Jane Cleary-Goldman; Fergal D Malone; T Flint Porter; David A Nyberg; Peter Bernstein; Mary E D'Alton;
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  199     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-30     Completed Date:  2008-07-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  62.e1-6     Citation Subset:  AIM; IM    
Affiliation:
Warren Alpert Medical School of Brown University, Providence, RI, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Autoantibodies / blood*
Female
Gestational Age
Humans
Pregnancy
Pregnancy Trimester, First / blood
Pregnancy Trimester, Second / blood
Reference Values
Thyrotropin / blood*
Thyroxine / blood*
Grant Support
ID/Acronym/Agency:
R01 HD 38652/HD/NICHD NIH HHS; R01 HD038652-01/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/anti-thyroglobulin; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin
Investigator
Investigator/Affiliation:
K Welch / ; R Denchy / ; R Ball / ; B Oshiro / ; L Cannon / ; K Nelson / ; C Loucks / ; A Yoshimura / ; D Luthy / ; S Coe / ; C Comstock / ; J Esler / ; R Bukowski / ; G Hankins / ; G Saade / ; J Lee / ; R Berkowitz / ; K Eddleman / ; Y Kharbutli / ; I Merkatz / ; S Carter / ; L Dugoff / ; J Hobbins / ; L Schultz / ; I Timor-Tritsch / ; M Paidas / ; J Borsuk / ; S Craigo / ; D Bianchi / ; B Isquith / ; B Berlin / ; S Carr / ; C Duquette / ; H Wolfe / ; R Baughman / ; J Hanson / ; F de la Cruz / ; K Dukes / ; T Tripp / ; D Emig / ; L Sullivan /
Comments/Corrections
Erratum In:
Am J Obstet Gynecol. 2008 Sep;199(3):326

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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