Document Detail

First- and second-order multivariate calibration applied to biological samples: determination of anti-inflammatories in serum and urine.
MedLine Citation:
PMID:  12373394     Owner:  NLM     Status:  MEDLINE    
First- and second-order multivariate calibration of fluorescence data have been compared as regards the determination of anti-inflammatories and metabolites in the biological fluids serum and urine. The simultaneous resolution of naproxen-salicylic acid mixtures in serum and naproxen-salicylic acid-salicyluric acid mixtures in urine was accomplished and employed for a discussion of the relative advantages of the applied chemometric tools. The analysis of second-order fluorescence excitation-emission matrices was performed using iteratively reweighted generalized rank annihilation method (IRGRAM), parallel factor analysis (PARAFAC), and self-weighted alternating trilinear decomposition (SWATLD). The results were compared with first-order fluorescence emission data analyzed with partial least-squares regression (PLS). In all cases, the performance of the methods was improved through the formation of inclusion complexes of the analytes with beta-cyclodextrin. The concentration ranges in which the analytes could be determined were as follows: naproxen, 0-250 ng mL(-1) in serum and 0-200 ng mL(-1) in urine; salicylic acid, 0-500 ng mL(-1) in serum and 0-300 ng mL(-1) in urine, and salicyluric acid, 0-300 ng mL(-1) in urine.
Juan A Arancibia; Alejandro C Olivieri; Graciela M Escandar
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2002-09-11
Journal Detail:
Title:  Analytical and bioanalytical chemistry     Volume:  374     ISSN:  1618-2642     ISO Abbreviation:  Anal Bioanal Chem     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-09     Completed Date:  2002-12-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101134327     Medline TA:  Anal Bioanal Chem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  451-9     Citation Subset:  IM    
Departamento de Química Analítica, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531 (S2002LRK) Rosario, Argentina.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / blood*,  urine*
Cyclodextrins / chemistry
Hippurates / urine
Least-Squares Analysis
Multivariate Analysis
Naproxen / blood,  urine
Salicylic Acid / blood,  urine
Spectrometry, Fluorescence / methods*,  standards
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Cyclodextrins; 0/Hippurates; 0/beta-Cyclodextrins; 22204-53-1/Naproxen; 487-54-7/salicylurate; 69-72-7/Salicylic Acid; 7585-39-9/betadex

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