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First results on citrinin biomarkers in urines from rural and urban cohorts in Bangladesh.
MedLine Citation:
PMID:  25488509     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Citrinin (CIT) is a mycotoxin contaminant in food commodities and can co-occur with ochratoxin A (OTA), another nephrotoxic contaminant in food and feed. Presence of OTA in maize from Bangladesh has been reported, but no data exist on CIT occurrence in food or feed in Bangladesh. Since biomonitoring provides the best approach to assess human exposure to contaminants from various sources and by all routes, a validated method for biomarker analysis has been used to investigate the presence of CIT and its metabolite dihydrocitrinone (HO-CIT) in urines from two Bangladeshi cohorts: Both analytes were determined in urine samples collected from inhabitants of a rural (n = 32) and an urban (n = 37) area in the Rajshahi district of Bangladesh. After cleanup by immunoaffinity columns, extracts were analyzed by LC-MS/MS; the limits of detection for CIT and HO-CIT in urine were 0.02 and 0.05 ng/mL, respectively. CIT and HO-CIT were detectable in 94 and 71 % of all urine samples. Urinary biomarker levels did not show significant correlations with age, gender, and body mass index of the donors. However, excretion of CIT together with its metabolite HO-CIT was significantly higher (p < 0.01) in the rural cohort (mean 1.1 ± 1.9 ng/mL) than in the urban cohort (mean 0.14 ± 0.14 ng/mL). This clearly indicates differences in mycotoxin exposure. As food habits differ between rural and urban people and also their main areas of occupation, further research is needed with regard to the major contributors of CIT exposure in the two cohorts. In conclusion, this first biomarker analysis indicates widespread and variable exposure to CIT in Bangladeshi adults.
Authors:
Nurshad Ali; Meinolf Blaszkewicz; Nayan Chandra Mohanto; Mashiur Rahman; Abdul Alim; Khaled Hossain; Gisela H Degen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-12-10
Journal Detail:
Title:  Mycotoxin research     Volume:  -     ISSN:  1867-1632     ISO Abbreviation:  Mycotoxin Res     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-9     Completed Date:  -     Revised Date:  2014-12-10    
Medline Journal Info:
Nlm Unique ID:  8807334     Medline TA:  Mycotoxin Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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