Document Detail

First reported clinical pregnancy following heterotopic grafting of cryopreserved ovarian tissue in a woman after a bilateral oophorectomy.
MedLine Citation:
PMID:  24014608     Owner:  NLM     Status:  MEDLINE    
Ovarian tissue cryopreservation and transplantation is a form of fertility preservation offered to young women at high risk of losing ovarian function after cancer treatment. While there have been successful births resulting from orthotopic site grafts, we report the first case of an ongoing pregnancy from a heterotopic graft in a patient who had previously undergone bilateral oopherectomy for a granulosa cell tumour. Frozen-thawed ovarian tissue was transplanted to the anterior abdominal wall. Subsequent ovarian stimulation and transabdominal ultrasound-guided oocyte retrieval from the grafts resulted in two oocytes. These were fertilized with ICSI and two embryos were transferred. Serial ultrasounds have confirmed an ongoing 26-week intrauterine twin pregnancy. Thus, this first demonstration of a pregnancy from a heterotopic graft site provides unequivocal evidence that cryopreservation preserves complete follicle development and that normal ovarian function can occur at a non-ovarian site. This provides optimism for further efforts to assist women who have had oophorectomy and pelvic surgery or radiotherapy, without an appropriate orthotopic site for grafting.
C J Stern; D Gook; L G Hale; F Agresta; J Oldham; G Rozen; T Jobling
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-09-07
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  28     ISSN:  1460-2350     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-10-14     Completed Date:  2014-06-16     Revised Date:  2014-08-19    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  2996-9     Citation Subset:  IM    
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MeSH Terms
Abdominal Wall / surgery
Embryo Transfer
Fertility Preservation / methods*
Oocyte Retrieval
Ovarian Follicle / physiology
Ovary / transplantation*
Ovulation Induction
Sperm Injections, Intracytoplasmic
Transplantation, Heterotopic
Comment In:
Hum Reprod. 2014 Aug;29(8):1828   [PMID:  24871346 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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