| First reported cases of intravascular large cell lymphoma of the NK cell type: clinical, histologic, immunophenotypic, and molecular features. | |
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MedLine Citation:
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PMID: 15743739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Most cases of intravascular large cell lymphoma are of B-cell phenotype, with a few cases of T-cell lineage and rare cases with histiocytic features described. A definitive natural killer (NK) cell variant has not been recognized. This report is the first to describe the clinical, histologic, immunophenotypic, and molecular features of 2 cases of intravascular lymphoma with an NK cell phenotype (CD3epsilon+, CD2+, CD7+, CD56+, T-cell intracytoplasmic antigen-1+, perforin+, granzyme B+, CD20-, CD4-, CD5-, CD8-, T-cell receptor [TCR]betaF1-). Molecular studies for TCR gene rearrangements revealed a germline configuration. A 41-year-old man had erythematous plaque-like subcutaneous lesions of the lower extremities in which biopsy revealed Epstein-Barr virus-positive intravascular lymphoma. Following chemotherapy and stem cell transplantation, he was alive with no evidence of disease at 1 year. A 47-year-old woman had myalgias, arthralgias, weakness, fever, altered mental status, and pancytopenia. Bone marrow biopsy demonstrated intravascular lymphoma. Therapy was initiated; however, her condition deteriorated rapidly, and she died. Autopsy revealed involvement of multiple organs, including brain, kidneys, ovaries, and bone marrow. These cases represent the first documented examples of an NK cell variant of intravascular lymphoma. |
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Authors:
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Huiqing Wu; Jonathan W Said; Elizabeth D Ames; Chen Chen; Valerie McWhorter; Peter Chen; Violette Ghali; Geraldine S Pinkus |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of clinical pathology Volume: 123 ISSN: 0002-9173 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-03-03 Completed Date: 2005-05-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 603-11 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, Brigham and Women's, Hospital and Harvard Medical School, Boston, MA 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD / analysis Brain / blood supply, pathology Female Gene Rearrangement Genes, T-Cell Receptor Humans Immunohistochemistry Immunophenotyping Killer Cells, Natural / metabolism*, pathology* Lymphoma, Large B-Cell, Diffuse / genetics, metabolism*, pathology* Male Middle Aged Polymerase Chain Reaction Skin / blood supply, pathology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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