Document Detail

First report of the use of meglumine antimoniate for treatment of canine leishmaniasis in a pregnant dog.
MedLine Citation:
PMID:  21164165     Owner:  NLM     Status:  In-Process    
Canine leishmaniasis during pregnancy is rarely reported, even in countries where the infection in dogs is endemic. The authors report a case of a 4 yr old bitch with leishmaniasis treated with meglumine antimoniate during pregnancy. The pregnancy and delivery were normal and the bitch presented improvement of the infection during treatment. Three puppies died within 2 days of birth and tested negative via real-time PCR for L. infantum. The two surviving puppies were followed clinically, serologically, and by real-time PCR until 1 yr of age with no evidence of congenital leishmaniasis. L. infantum DNA was detected with real-time PCR analysis of uterine tissue from the bitch at the time of ovariohysterectomy. PCR analysis was performed after an ovariohysterectomy of the bitch that was performed two months after parturition. Meglumine antimoniate use in the pregnant bitch may have prevented vertical transmission of leishmaniasis.
Eva Spada; Daniela Proverbio; Debora Groppetti; Roberta Perego; Valeria Grieco; Elisabetta Ferro
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Publication Detail:
Type:  Journal Article     Date:  2010-12-16
Journal Detail:
Title:  Journal of the American Animal Hospital Association     Volume:  47     ISSN:  1547-3317     ISO Abbreviation:  J Am Anim Hosp Assoc     Publication Date:    2011 Jan-Feb
Date Detail:
Created Date:  2010-12-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0415027     Medline TA:  J Am Anim Hosp Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  67-71     Citation Subset:  IM    
Department of Veterinary Clinical Science, Faculty of Veterinary Medicine, University of Milan, Italy.
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