| First-pass whole-body magnetic resonance angiography (MRA) using the blood-pool contrast medium gadofosveset trisodium: comparison to gadopentetate dimeglumine. | |
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MedLine Citation:
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PMID: 17700282 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To evaluate gadofosveset trisodium for first-pass magnetic resonance angiography (MRA) in the setting of whole-body MRA (WB-MRA). MATERIALS AND METHODS: Forty patients were examined using either 10 mL gadofosveset trisodium (n = 20) or 30 mL gadopentetate dimeglumine (n = 20), followed by arterial-phase imaging of 4 consecutive anatomic regions. Signal intensity was measured in 2 vessels per region. Relative contrast values (RC) were calculated. Arterial contrast, venous overlay, and image quality were rated by 2 radiologists. The Mann-Whitney U test was used to test for significance. RESULTS: Compared with gadopentetate dimeglumine, gadofosveset trisodium enhanced imaging revealed higher RC values in 2 vessel regions, with the differences being significant in 3 of 4 vessel segments. Gadofosveset trisodium revealed lower RC values in 2 regions with significant differences in 2 segments. Qualitative evaluation revealed higher ratings for gadofosveset trisodium regarding all 3 criteria with significant differences in 2 regions. CONCLUSIONS: Gadofosveset trisodium serves well for first-pass imaging in WB-MRA. |
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Authors:
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Christian Klessen; Patrick A Hein; Alexander Huppertz; Matthias Voth; Moritz Wagner; Thomas Elgeti; Hannes Kroll; Bernd Hamm; Matthias Taupitz; Patrick Asbach |
Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article |
Journal Detail:
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Title: Investigative radiology Volume: 42 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-16 Completed Date: 2007-11-13 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 659-64 Citation Subset: IM |
Affiliation:
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Department of Radiology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany. christian.klessen@charite.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arterial Occlusive Diseases
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diagnosis* Contrast Media Female Gadolinium / diagnostic use* Gadolinium DTPA / diagnostic use* Humans Image Enhancement / methods Information Storage and Retrieval / methods* Magnetic Resonance Angiography / methods* Male Middle Aged Organometallic Compounds / diagnostic use* Reproducibility of Results Sensitivity and Specificity Whole Body Imaging / methods* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Organometallic Compounds; 0/gadofosveset trisodium; 7440-54-2/Gadolinium; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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