Document Detail


First pass uptake of fentanyl, meperidine, and morphine in the human lung.
MedLine Citation:
PMID:  3310739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The first pass uptake of fentanyl, meperidine, and morphine in human lung was studied in patients using a double indicator dilution technique. A bolus containing one of the drugs and indocyanine green dye (ICG) was rapidly injected into the central venous catheter of patients prior to anesthesia for surgery. Sequential arterial blood samples were collected at 1-s intervals for 45 s after injection. The total amount of drug taken up by the lung during the first pass and the instantaneous extraction of drug at each time point during the first pass were calculated from the differences in the arterial blood concentration versus time curves of the nondiffusible indicator (ICG) and the drug. The total uptake (mean +/- SE) during the first pass through the human lung for fentanyl and meperidine was 75.2 +/- 3.2% and 64.7 +/- 7.8% of the injected dose, respectively. The pulmonary uptake of morphine was very small, with 96.5 +/- 7.1% of the injected dose recovered in arterial blood after the first pass through the lung. The arterial blood concentration of drug and dye versus time showed a slight delay of the fentanyl and meperidine peaks compared to ICG. It was also observed that greater than 90% of these drugs were extracted from the blood in the early part of the first pass, but the extraction decreased with time during the first pass through the lung. These findings indicate that some of the drug taken up by the lung can diffuse back out into the blood.2+off
Authors:
D L Roerig; K J Kotrly; E J Vucins; S B Ahlf; C A Dawson; J P Kampine
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Anesthesiology     Volume:  67     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-11-10     Completed Date:  1987-11-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  466-72     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee.
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MeSH Terms
Descriptor/Qualifier:
Aged
Dye Dilution Technique
Fentanyl / blood,  metabolism*
Humans
Lung / metabolism*
Meperidine / blood,  metabolism*
Middle Aged
Morphine / blood,  metabolism*
Chemical
Reg. No./Substance:
437-38-7/Fentanyl; 57-27-2/Morphine; 57-42-1/Meperidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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