Document Detail


First-pass pulmonary retention of sufentanil at three different background blood concentrations of the opioid.
MedLine Citation:
PMID:  7880706     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using a double-indicator technique, we have studied, in 10 patients undergoing aorto-coronary bypass surgery, first-pass pulmonary retention of sufentanil. Pulmonary retention was studied at three pseudo steady-state background blood concentrations of 2.8 (0.66), 6.9 (1.2) and 15.9 (2.6) ng ml-1, respectively, produced by a computer-controlled infusion. Mean first-pass pulmonary retentions at these concentrations were 68 (95% confidence intervals 62-73), 65 (60-70) and 60 (52-67)%, respectively. First-pass pulmonary retention of sufentanil was significantly lower at the highest background concentration compared with the lowest background concentration. First-pass pulmonary retention of sufentanil was partly saturable in the range of concentrations used for clinical purposes.
Authors:
F Boer; F H Engbers; J G Bovill; A G Burm; A Hak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  74     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-04-11     Completed Date:  1995-04-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  50-5     Citation Subset:  IM    
Affiliation:
Department of Anaesthesiology, University Hospital Leiden, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Coronary Artery Bypass
Humans
Lung / metabolism*
Sufentanil / blood*,  pharmacokinetics*
Chemical
Reg. No./Substance:
56030-54-7/Sufentanil

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