| First-pass pulmonary retention of sufentanil at three different background blood concentrations of the opioid. | |
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MedLine Citation:
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PMID: 7880706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using a double-indicator technique, we have studied, in 10 patients undergoing aorto-coronary bypass surgery, first-pass pulmonary retention of sufentanil. Pulmonary retention was studied at three pseudo steady-state background blood concentrations of 2.8 (0.66), 6.9 (1.2) and 15.9 (2.6) ng ml-1, respectively, produced by a computer-controlled infusion. Mean first-pass pulmonary retentions at these concentrations were 68 (95% confidence intervals 62-73), 65 (60-70) and 60 (52-67)%, respectively. First-pass pulmonary retention of sufentanil was significantly lower at the highest background concentration compared with the lowest background concentration. First-pass pulmonary retention of sufentanil was partly saturable in the range of concentrations used for clinical purposes. |
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Authors:
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F Boer; F H Engbers; J G Bovill; A G Burm; A Hak |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of anaesthesia Volume: 74 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 1995 Jan |
Date Detail:
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Created Date: 1995-04-11 Completed Date: 1995-04-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 50-5 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology, University Hospital Leiden, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Coronary Artery Bypass Humans Lung / metabolism* Sufentanil / blood*, pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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56030-54-7/Sufentanil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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