| First-pass dynamic contrast-enhanced MRI with extravasating contrast reagent: evidence for human myocardial capillary recruitment in adenosine-induced hyperemia. | |
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MedLine Citation:
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PMID: 18727151 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human myocardial (1)H(2)O T(1)-weighted dynamic contrast-enhanced MRI data were acquired during the brief first-pass period after injection of a very small gadolinium diethylenetriaminepenta-acetate (GdDTPA(2-)) dose. The shutter-speed pharmacokinetic effects of both transendothelial and transcytolemmal equilibrium water exchange processes were investigated. Our results indicate that even for such a short acquisition window and relatively large pseudo-first-order rate constant (K(trans)) for plasma/interstitium contrast reagent (CR) transfer the kinetics of these water exchange processes cannot be treated as infinitely fast or slow. However, neither the intracellular water molecule lifetime (tau(i)) nor its intravascular counterpart (tau(b)) are among the parameters most influential in analysis of the noisy data typically associated with the cardiac perfusion application. Thus, the actual values of water exchange kinetic rate constants are relatively indeterminate as this experiment is usually conducted. Combining the K(trans) evaluations with independently determined flow (F) values allows us to estimate CR permeability coefficient surface area product (P(CR)S) values. The fact that the P(CR)S magnitudes almost equal the K(trans) values confirms that GdDTPA(2-) extravasation in resting human myocardial muscle is indeed permeation-limited and supports the validity of the K(trans) and P(CR)S estimations. Nevertheless the model analysis is most consistent with the results if P(CR)S is not assumed to be constant with changing flow. The capillary blood volume fraction (v(b)) is a sensitive parameter in the analysis. We also compared resting and hyperemic cardiac conditions, the latter resulting from the volume flow increase induced by adenosine arteriolar vasodilation. We found that the P(CR)S value increases with flow probably mostly because of an S increase associated with capillary recruitment. The v(b) values also increased in hyperemia and showed a flow-dependence with a clearly identifiable component due to capillary recruitment. |
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Authors:
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Xin Li; Charles S Springer; Michael Jerosch-Herold |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: NMR in biomedicine Volume: 22 ISSN: 0952-3480 ISO Abbreviation: NMR Biomed Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-09 Completed Date: 2009-04-16 Revised Date: 2011-01-17 |
Medline Journal Info:
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Nlm Unique ID: 8915233 Medline TA: NMR Biomed Country: England |
Other Details:
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Languages: eng Pagination: 148-57 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2008 John Wiley & Sons, Ltd. |
Affiliation:
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Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR 97239, USA. lxin@ohsu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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diagnostic use* Aged Aged, 80 and over Capillary Permeability* Computer Simulation Contrast Media / pharmacokinetics Extravasation of Diagnostic and Therapeutic Materials / diagnosis*, metabolism* Female Gadolinium DTPA / diagnostic use*, pharmacokinetics* Heart / anatomy & histology Humans Hyperemia / diagnosis* Image Interpretation, Computer-Assisted / methods Male Middle Aged Models, Cardiovascular Myocardium / metabolism* Reproducibility of Results Sensitivity and Specificity |
| Grant Support | |
ID/Acronym/Agency:
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R01 EB000422-19/EB/NIBIB NIH HHS; R01 EB000422-20/EB/NIBIB NIH HHS; R01 EB000422-21/EB/NIBIB NIH HHS; R01 EB000422-22/EB/NIBIB NIH HHS; R01 EB000422-23/EB/NIBIB NIH HHS; R01 EB000422-24/EB/NIBIB NIH HHS; R01 NS040801-01/NS/NINDS NIH HHS; R01 NS040801-02/NS/NINDS NIH HHS; R01 NS040801-03/NS/NINDS NIH HHS; R01 NS040801-04/NS/NINDS NIH HHS; R01 NS040801-05/NS/NINDS NIH HHS; R01 NS040801-06A1/NS/NINDS NIH HHS; R01-EB00422/EB/NIBIB NIH HHS; R01-HL65580/HL/NHLBI NIH HHS; R01-NS40801/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 58-61-7/Adenosine; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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