Document Detail

First-line therapy with latanoprost 0.005% results in improved ocular circulation in newly diagnosed primary open-angle glaucoma patients: a prospective, 6-month, open-label study.
MedLine Citation:
PMID:  17115020     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the effect of latanoprost 0.005% on the optic nerve head (ONH) and retinal circulation of newly diagnosed and previously untreated primary open-angle glaucoma (POAG) patients. METHODS: Twenty-two newly diagnosed and previously untreated POAG patients (mean age+/-SD: 68.38+/-11.92 years) were included in this longitudinal open-label study. Patients were treated with latanoprost 0.005% once a day. Intraocular pressure (IOP), systemic blood pressure (BP), mean ocular perfusion pressure (MOPP), and ocular perfusion parameters 'volume', 'velocity', and 'flow' measured at the optic nerve head (ONH) and retina by means of Heidelberg Retina Flowmeter system were evaluated during a 6-month follow-up period. RESULTS: Treatment with latanoprost 0.005% resulted in a significant decrease in IOP (P<0.0001) and increase in MOPP (P<0.0001). After correcting for changes in MOPP, the blood velocity measured at the ONH level was significantly higher after 6 months of treatment than at baseline (P=0.0310). In addition, blood volume and flow measured at the peripapillary retina level improved after 3 and 6 months of treatment (P=0.0170; P=0.0260, and P=0.0170; P=0.0240 respectively). CONCLUSION: Previously untreated POAG patients exhibit reduced IOP, increased MOPP and improved ocular perfusion at the ONH and retina levels when treated with Latanoprost 0.005%. These effects could be beneficial for glaucoma patients suffering from ocular vascular dysregulation.
D Gherghel; S L Hosking; I A Cunliffe; R A Armstrong
Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2006-11-17
Journal Detail:
Title:  Eye (London, England)     Volume:  22     ISSN:  0950-222X     ISO Abbreviation:  Eye (Lond)     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-13     Completed Date:  2008-09-10     Revised Date:  2010-03-23    
Medline Journal Info:
Nlm Unique ID:  8703986     Medline TA:  Eye (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  363-9     Citation Subset:  IM    
School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, UK.
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MeSH Terms
Administration, Topical
Antihypertensive Agents / administration & dosage*
Blood Flow Velocity / drug effects
Eye / blood supply*
Glaucoma, Open-Angle / drug therapy*,  physiopathology
Intraocular Pressure / drug effects
Prospective Studies
Prostaglandins F, Synthetic / administration & dosage*
Treatment Outcome
Reg. No./Substance:
0/Antihypertensive Agents; 0/Prostaglandins F, Synthetic; 130209-82-4/latanoprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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