| First human experience with angiopeptin-eluting stent: a quantitative coronary angiography and three-dimensional intravascular ultrasound study. | |
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MedLine Citation:
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PMID: 16208695 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Angiopeptin has been shown to reduce in-stent restenosis in various animal models. Meanwhile, BiodivYsio DD phosphorylcholine (PC)-coated stent provides a platform for local delivery of antiproliferative agents to the coronary artery. We studied the feasibility, safety, and impact on tissue growth of angiopeptin-eluting BiodivYsio DD PC-coated stents in human native de novo coronary lesions. We enrolled 14 patients (16 lesions) who underwent intravascular ultrasound (IVUS)-guided angiopeptin-eluting stent implantation in native coronary arteries between 3.0 and 4.0 mm in diameter with lesion length<or=18 mm. We successfully implanted 13 stents loaded with 22 microg of angiopeptin and three stents with 126 microg of angiopeptin. No major adverse cardiac events or target vessel failure occurred at 1-year clinical follow-up. All patients underwent 6-month angiographic and volumetric IVUS follow-up. In-stent late loss was 0.46+/-0.32 mm in the low-dose group and 0.26+/-0.14 mm in the high-dose group. Binary restenosis rate was 0%. Follow-up percentage neointimal hyperplasia by IVUS was 18.4%+/-22.5% for the low-dose group and 10.2%+/-5.8% for the high-dose group, respectively. There were no edge effect and late stent malapposition. Angiopeptin-eluting BiodivYsio DD PC stent appears feasible and safe in treating native de novo coronary lesions with modest degree of neointimal hyperplasia. |
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Authors:
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On-Hing Kwok; Wing-Hing Chow; Tin-Chu Law; Alex Chiu; William Ng; Wai-Fat Lam; Mun K Hong; Jeffrey J Popma |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions Volume: 66 ISSN: 1522-1946 ISO Abbreviation: Catheter Cardiovasc Interv Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-11-28 Completed Date: 2006-04-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100884139 Medline TA: Catheter Cardiovasc Interv Country: United States |
Other Details:
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Languages: eng Pagination: 541-6 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2005 Wiley-Liss, Inc. |
Affiliation:
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Division of Cardiology, Grantham Hospital, Hong Kong, and Division of Cardiology, Weill Cornell Medical College, New York, NY, USA. vohkwok@hksh.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Vessel Prosthesis Implantation
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instrumentation* Cardiovascular Agents / pharmacology Coated Materials, Biocompatible* Coronary Angiography* Coronary Stenosis / radiography, surgery*, ultrasonography Feasibility Studies Female Follow-Up Studies Humans Male Middle Aged Oligopeptides / pharmacology* Prospective Studies Somatostatin / analogs & derivatives*, pharmacology Stents* Treatment Outcome Ultrasonography, Interventional / methods* |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents; 0/Coated Materials, Biocompatible; 0/Oligopeptides; 113294-82-9/angiopeptin; 51110-01-1/Somatostatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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