Document Detail

First-generation agents: aspirin, heparin and coumarins.
MedLine Citation:
PMID:  15171956     Owner:  NLM     Status:  MEDLINE    
Aspirin, heparin and the coumarins are the classical anti-thrombotic agents. They represent the platform upon which newer drugs holding the promise of greater efficacy and less toxicity are being developed. Even as such newer drugs arrive into clinical practice, the older agents remain remarkable for their decades-long pre-eminence. All derive from natural sources, and none from a search for therapeutic anti-thrombotic agents; they have saved countless lives but also served as essential probes into basic mechanisms of thrombosis. Testament to their clinical importance is that these agents are the only drugs profiled on a regular basis in special scientific statements by the American Heart Association/American College of Cardiology and by the American College of Chest Physicians. This chapter reviews their biology, uses and limitations.
Richard L Mueller
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Best practice & research. Clinical haematology     Volume:  17     ISSN:  1521-6926     ISO Abbreviation:  Best Pract Res Clin Haematol     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-06-02     Completed Date:  2005-02-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101120659     Medline TA:  Best Pract Res Clin Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  23-53     Citation Subset:  IM    
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MeSH Terms
Aspirin / adverse effects,  pharmacology,  therapeutic use
Cardiovascular Diseases / complications,  drug therapy,  prevention & control
Coumarins / adverse effects,  pharmacology,  therapeutic use
Fibrinolytic Agents / adverse effects,  pharmacology*,  therapeutic use
Heparin / adverse effects,  pharmacology,  therapeutic use
Practice Guidelines as Topic
Treatment Outcome
Reg. No./Substance:
0/Coumarins; 0/Fibrinolytic Agents; 50-78-2/Aspirin; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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