| First forty-eight hours of developing otitis media: an experimental study. | |
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MedLine Citation:
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PMID: 12834127 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The early inflammatory changes in the tympanic membrane were explored in 2 rat models. Acute otitis media was induced by instillation of Streptococcus pneumoniae type 3 into the middle ear cavity, and otitis media with effusion was induced by blockage of the eustachian tube. Otomicroscopic examination was performed before the rats were painlessly sacrificed at 3, 6, 9, 12, 18, 24, or 48 hours after initiation of the otitis media conditions. The tympanic membrane was studied by light and electron microscopy. Both acute otitis media and otitis media with effusion caused early inflammatory changes of the tympanic membrane, and the pars flaccida was the portion that reacted first. The inflammatory alterations were most pronounced in the acute otitis media model. The course of inflammation showed a bimodal pattern with an early deposition of a filamentous material with a band pattern, typical of fibrin. Despite a fluid-filled middle ear cavity, the inflammatory changes in the otitis media with effusion model were moderate, as was consistent with the clinical appearance of the tympanic membrane. |
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Authors:
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Per Olof Eriksson; Cecilia Mattsson; Sten Hellström |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Annals of otology, rhinology, and laryngology Volume: 112 ISSN: 0003-4894 ISO Abbreviation: Ann. Otol. Rhinol. Laryngol. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-07-01 Completed Date: 2003-07-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0407300 Medline TA: Ann Otol Rhinol Laryngol Country: United States |
Other Details:
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Languages: eng Pagination: 558-66 Citation Subset: AIM; IM |
Affiliation:
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Department of Clinical Sciences, Division of Otorhinolaryngology, Umeå University Hospital, Umeå, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Disease Models, Animal Disease Progression Male Otitis Media with Effusion / microbiology*, pathology* Rats Rats, Sprague-Dawley Streptococcal Infections / complications Streptococcus pneumoniae Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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