Document Detail

First finite element model of the left ventricle with mitral valve: insights into ischemic mitral regurgitation.
MedLine Citation:
PMID:  20417775     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Left ventricular remodeling after posterobasal myocardial infarction can lead to ischemic mitral regurgitation. This occurs as a consequence of leaflet tethering due to posterior papillary muscle displacement.
METHODS: A finite element model of the left ventricle, mitral apparatus, and chordae tendineae was created from magnetic resonance images from a sheep that developed moderate mitral regurgitation after posterobasal myocardial infarction. Each region of the model was characterized by a specific constitutive law that captured the material response when subjected to physiologic pressure loading.
RESULTS: The model simulation produced a gap between the posterior and anterior leaflets, just above the infarcted posterior papillary muscle, which is indicative of mitral regurgitation. When the stiffness of the infarct region was reduced, this caused the wall to distend and the gap area between the leaflets to increase by 33%. Additionally, the stress in the leaflets increased around the chordal connection points near the gap.
CONCLUSIONS: The methodology outlined in this work will allow a finite element model of both the left ventricle and mitral valve to be generated using noninvasive techniques.
Jonathan F Wenk; Zhihong Zhang; Guangming Cheng; Deepak Malhotra; Gabriel Acevedo-Bolton; Mike Burger; Takamaro Suzuki; David A Saloner; Arthur W Wallace; Julius M Guccione; Mark B Ratcliffe
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  89     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-26     Completed Date:  2010-06-03     Revised Date:  2013-07-18    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1546-53     Citation Subset:  AIM; IM    
Copyright Information:
Copyright (c) 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
Department of Surgery, University of California, San Francisco, California, USA.
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MeSH Terms
Blood Flow Velocity
Chordae Tendineae / pathology,  physiopathology
Disease Models, Animal
Echocardiography, Doppler, Color
Finite Element Analysis*
Heart Ventricles / physiopathology
Image Enhancement
Magnetic Resonance Imaging
Mitral Valve / pathology,  physiopathology
Mitral Valve Insufficiency / etiology,  physiopathology*
Models, Cardiovascular*
Myocardial Contraction
Myocardial Infarction / complications*,  physiopathology
Papillary Muscles / physiopathology
Sensitivity and Specificity
Ventricular Remodeling / physiology*
Grant Support
R01 HL063348-10A1/HL/NHLBI NIH HHS; R01 HL077921-04/HL/NHLBI NIH HHS; R01 HL084431/HL/NHLBI NIH HHS; R01 HL084431-04/HL/NHLBI NIH HHS; R01 HL086400/HL/NHLBI NIH HHS; R01 HL086400-02/HL/NHLBI NIH HHS; R01-HL-63348/HL/NHLBI NIH HHS; R01-HL-77921/HL/NHLBI NIH HHS; R01-HL-84431/HL/NHLBI NIH HHS; R01-HL-86400/HL/NHLBI NIH HHS
Comment In:
Ann Thorac Surg. 2010 May;89(5):1554   [PMID:  20417776 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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