Document Detail

First detection of anatoxin-a in human and animal dietary supplements containing cyanobacteria.
MedLine Citation:
PMID:  19520132     Owner:  NLM     Status:  MEDLINE    
Anatoxin-a is a potent neurotoxin produced by several species of cyanobacteria. This alkaloid may cause fatal intoxication to exposed organisms and this has raised concerns over the increasing popularity of food supplements containing cyanobacteria. These are being marketed with alleged health properties for animal and human consumption. These supplements most commonly contain the genera Spirulina (Arthrospira) and Aphanizomenon and their consumption represent a potential route for anatoxin-a exposure in cases where adequate quality control is not undertaken. In this work, several dietary supplements containing cyanobacteria from different commercial suppliers were evaluated for the presence of anatoxin-a by high performance liquid chromatography with fluorescence detection. Additionally, the presence of the previously derivatized anatoxin-a was confirmed by using Gas chromatography-mass spectrometry. A total of 39 samples were analysed in the study. Results showed that three of the samples (7.7%) contained anatoxin-a, at concentrations ranging from 2.50 to 33 microg g(-1). Quality control of cyanobacterial food supplements is required to avoid potential health effects in humans and animals.
Sandra Rellán; Joana Osswald; Martin Saker; Ana Gago-Martinez; Vitor Vasconcelos
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-09
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  47     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-11     Completed Date:  2009-10-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2189-95     Citation Subset:  IM    
Departamento de Química Analítica y Alimentaria, Facultad de Química, Edificio de Ciencias Experimentales, Campus Universitario, Universidad de Vigo, Vigo, Spain.
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MeSH Terms
Anabaena / isolation & purification,  metabolism*
Chromatography, High Pressure Liquid
Dietary Supplements / analysis*,  microbiology*,  standards
Food Microbiology*
Gas Chromatography-Mass Spectrometry
Spirulina / isolation & purification,  metabolism*
Tropanes / analysis*
Reg. No./Substance:
0/Tropanes; 0/anatoxin a

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