| First description of "Indian childhood cirrhosis" in a non-Indian infant in Europe. | |
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MedLine Citation:
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PMID: 2919520 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The first female child of healthy German parents, breast-fed for 5 weeks, developed progressive abdominal distension due to hepatosplenomegaly at the age of 7 months and died from acute liver failure 3 months later. Histology showed destruction of liver architecture with extreme hepatocellular copper storage, characteristic of "Indian childhood cirrhosis" (ICC). The family received drinking water from a well via copper pipes. The copper level of the water was extremely elevated (430 and 5510 micrograms/l) so that exogenous copper intake during the first months of life may have induced the fatal liver disease, probably in association with an unproven genetic disposition. This is the first description of a case of ICC in a member of a non-Indian family in Europe. |
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Authors:
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M Weiss; J Müller-Höcker; B Wiebecke; B H Belohradsky |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Acta paediatrica Scandinavica Volume: 78 ISSN: 0001-656X ISO Abbreviation: Acta Paediatr Scand Publication Date: 1989 Jan |
Date Detail:
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Created Date: 1989-03-24 Completed Date: 1989-03-24 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0000211 Medline TA: Acta Paediatr Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 152-6 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, University of München, FRG. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Copper
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administration & dosage,
metabolism Female Germany, West Humans Infant Liver / pathology Liver Cirrhosis / diagnosis*, etiology, metabolism Prognosis Water Supply / analysis |
| Chemical | |
Reg. No./Substance:
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7440-50-8/Copper |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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