Document Detail


First description of "Indian childhood cirrhosis" in a non-Indian infant in Europe.
MedLine Citation:
PMID:  2919520     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The first female child of healthy German parents, breast-fed for 5 weeks, developed progressive abdominal distension due to hepatosplenomegaly at the age of 7 months and died from acute liver failure 3 months later. Histology showed destruction of liver architecture with extreme hepatocellular copper storage, characteristic of "Indian childhood cirrhosis" (ICC). The family received drinking water from a well via copper pipes. The copper level of the water was extremely elevated (430 and 5510 micrograms/l) so that exogenous copper intake during the first months of life may have induced the fatal liver disease, probably in association with an unproven genetic disposition. This is the first description of a case of ICC in a member of a non-Indian family in Europe.
Authors:
M Weiss; J Müller-Höcker; B Wiebecke; B H Belohradsky
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  78     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-03-24     Completed Date:  1989-03-24     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  152-6     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, University of München, FRG.
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MeSH Terms
Descriptor/Qualifier:
Copper / administration & dosage,  metabolism
Female
Germany, West
Humans
Infant
Liver / pathology
Liver Cirrhosis / diagnosis*,  etiology,  metabolism
Prognosis
Water Supply / analysis
Chemical
Reg. No./Substance:
7440-50-8/Copper

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