| First-degree heart block in the fetus of an anti-SSA/Ro-positive mother: reversal after a short course of dexamethasone treatment. | |
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MedLine Citation:
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PMID: 15248221 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Isolated congenital heart block is almost invariably associated with the presence of antibodies to SSA/Ro and SSB/La antigens in the maternal circulation. Once established, third-degree congenital heart block is permanent. However, a lesser degree of autoantibody-associated heart block in a fetus can be reversed if it is recognized and treated early enough with fluorinated glucocorticosteroids. The only method available clinically for the recognition of first-degree heart block in a fetus is measurement of the mechanical PR interval by pulsed Doppler echocardiography. This is the first report of a fetus in whom a diagnosis of first-degree heart block and the consequent decision to intervene were based solely on this technique. In addition, the first-degree heart block resolved completely after only 2 weeks of dexamethasone treatment, and the heart rhythm remained stable throughout the remainder of the pregnancy despite early discontinuation of therapy due to oligohydramnios. |
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Authors:
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Samo Vesel; Uros Mazić; Tanja Blejec; Tomaz Podnar |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Arthritis and rheumatism Volume: 50 ISSN: 0004-3591 ISO Abbreviation: Arthritis Rheum. Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-07-12 Completed Date: 2004-08-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: United States |
Other Details:
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Languages: eng Pagination: 2223-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Cardiology, Unit, University Medical Center Ljubljana, Ljubljana, Slovenia. samo.vesel@mf.uni-lj.si |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies, Antinuclear / blood* Dexamethasone / therapeutic use* Echocardiography, Doppler, Pulsed Female Fetal Heart* Glucocorticoids / therapeutic use* Heart Block / drug therapy*, ultrasonography Humans Pregnancy / blood, immunology* Treatment Outcome Ultrasonography, Prenatal |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antinuclear; 0/Glucocorticoids; 0/SS-A antibodies; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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