| First clinical experience with isradipine in the treatment of hypertension in Portugal. | |
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MedLine Citation:
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PMID: 1720485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy and safety of isradipine and nifedipine retard were compared in 51 patients with mild-to-moderate essential hypertension. A 4-week placebo run-in period was followed by an 8-week course of treatment. Patients were randomly allocated to either isradipine 1.25 mg twice daily (n = 24) or nifedipine 20 mg twice daily (n = 826); dosages were doubled if blood pressure was not normalized [diastolic blood pressure greater than or equal to 90 mm Hg) after 4 weeks of active treatment. Systolic/diastolic blood pressures were significantly reduced (p less than 0.01/p less than 0.01) by isradipine from 162/103 to 145/89 mm Hg, and by nifedipine from 162/104 to 143/88 mm Hg. Normalization rates were 79% with isradipine and 67% with nifedipine. It was necessary to double the dosage in seven of the patients taking isradipine and in three of those taking nifedipine; the mean final dosages were 1.63 mg and 22.4 mg twice daily, respectively. Heart rate did not change significantly with either treatment. There were drug-related adverse events in five patients (21%) taking isradipine (2 edema, 2 headache, 2 palpitations, 1 flushing) and in eight (30%) of those taking nifedipine (5 edema, 2 headache, 1 palpitations). Therapy was withdrawn in one patient in the isradipine group (1 headache) and two patients in the nifedipine group (1 edema, 1 headache). We conclude that isradipine is a highly effective and well tolerated antihypertensive agent. |
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Authors:
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F Rocha-Gonçalves; G Mariano-Pego; J Viegas; J M Correia; M A Botelho |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 18 Suppl 3 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1991 |
Date Detail:
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Created Date: 1992-01-09 Completed Date: 1992-01-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S4-6 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Faculty of Medicine, University of Oporto, Portugal. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antihypertensive Agents / adverse effects, therapeutic use* Blood Pressure / drug effects Calcium Channel Blockers / adverse effects, therapeutic use* Dihydropyridines / adverse effects, therapeutic use* Double-Blind Method Female Heart Rate / drug effects Humans Hypertension / blood, drug therapy*, physiopathology Isradipine Male Middle Aged Nifedipine / therapeutic use Portugal |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Calcium Channel Blockers; 0/Dihydropyridines; 21829-25-4/Nifedipine; 75695-93-1/Isradipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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