Document Detail

First case report of neurobrucellosis associated with hydrocephalus.
MedLine Citation:
PMID:  18499339     Owner:  NLM     Status:  MEDLINE    
Brucellosis is a common zoonosis in many parts of the world, including Mediterranean and Middle Eastern countries. The disease is primarily related to occupations at risk, such as veterinarians, farmers, laboratory technicians, abattoir workers, and others working with animals and their products. Neurologic complications of brucellosis are quite rare, ranging from 1.7 to 10% of those infected. To date, no cases of neurobrucellosis with hydrocephalus have been reported. A 38-year-old right-handed farmer complained of headaches, nausea, vomiting, gait disturbance, and sweating for 2 days. He also complained of bilateral hearing loss of 4 months duration. On neurologic examination, dysmmetry, dysdiadochokinesis, ataxia on the left, and bilateral sensorineural hearing loss existed. On cranial MRI, a communicating hydrocephalus was noted. Because the patient consumed fresh sheep cheese and was a farmer, brucellosis was considered in the differential diagnosis. Brucella agglutination was positive with a 1/320 titer in the blood and a 1/80 titer in the cerebrospinal fluid. Ceftriaxone, doxycycline, and rifampicin were administered and by the fourth week of treatment, the ataxia was markedly improved, and the patient was able to walk without support. His cranial MRI demonstrated a total regression of the hydrocephalus. As a result, we suggest that neurobrucellosis should be considered in patients with hydrocephalus, especially if they live in an endemic area for brucellosis, even in the absence of other systemic signs.
Figen Guney; Haluk Gumus; Aysegul Ogmegul; Bahar Kandemir; Dilek Emlik; Ugur Arslan; Inci Tuncer
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-05-21
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  110     ISSN:  0303-8467     ISO Abbreviation:  Clin Neurol Neurosurg     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-14     Completed Date:  2008-09-15     Revised Date:  2009-10-14    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  739-42     Citation Subset:  IM    
Selcuk University, Meram Medical Faculty, Department of Neurology, Akyokus, Konya, Turkey.
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MeSH Terms
Agricultural Workers' Diseases / diagnosis,  drug therapy
Anti-Bacterial Agents / therapeutic use
Brucellosis / complications*,  diagnosis,  drug therapy
Diagnosis, Differential
Hydrocephalus / etiology*,  pathology
Magnetic Resonance Imaging
Neurologic Examination
Occupational Diseases / complications*,  diagnosis,  drug therapy
Treatment Outcome
Reg. No./Substance:
0/Anti-Bacterial Agents

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